Varaico: Literature-Extracted Genetic Variants

Gene:CCND1
Variant:p.K112E
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CCND1

NM_053056.3:p.K112E

Associated Papers

Meta-Analysis of Gene Expression in Bulk-Processed Post-Mortem Spinal Cord from ALS Patients and Normal Controls.

Swindell WR

Neurosci, 2025

40700130 (PubMed )
Supplement: neurosci-06-00065-s001.zip › neurosci-3659146-supplementary › Supplementary_Material_File_S2.xlsx › _L__MSigDB

D-Type Cyclins in Development and Disease.

Saleban M et al.

Genes, 2023

Exploring YAP1-centered networks linking dysfunctional CFTR to epithelial-mesenchymal transition.

Quaresma MC et al.

Life Science Alliance, 2022

35500936 (PubMed )
Supplement: LSA-2021-01326_Supplemental_Data_5.xlsx › datatset_s5

RhoA-ROCK competes with YAP to regulate amoeboid breast cancer cell migration in response to lymphatic-like flow.

Mohammadalipour A et al.

Faseb Bioadvances, 2022

35520391 (PubMed )
Supplement: FBA2-4-342-s007.zip › fba21305-sup-0003-2021-00055-T-sup-0004--S.xlsx › MSigDB_c6_Oncogenic_Signatures

Selection of established tumour cells through narrow diameter micropores enriches for elevated Ras/Raf/MEK/ERK MAPK signalling and enhanced tumour growth.

Rudzka DA et al.

Small Gtpases, 2021

32569510 (PubMed )
Supplement: KSGT_A_1780108_SM3666.zip › Supplemental_Table_S6.xlsx › overlap

Multi-omic analysis elucidates the genetic basis of hydrocephalus.

Hale AT et al.

Cell Reports, 2021

33951428 (PubMed )
Supplement: NIHMS1700548-supplement-3.xlsx › All_tissues

A cyclin D-CDK6 dimer helps to reshuffle cyclin-dependent kinase inhibitors (CKI) to overcome TGF-beta-mediated arrest and maintain CDK2 activity.

Nataraj SE et al.

Cell Cycle (georgetown, Tex.), 2021

The double dealing of cyclin D1.

Tchakarska G et al.

Cell Cycle (georgetown, Tex.), 2020

Targeting Cyclin D-CDK4/6 Sensitizes Immune-Refractory Cancer by Blocking the SCP3-NANOG Axis.

Oh SJ et al.

Cancer Research, 2018

Pan-cancer screen for mutations in non-coding elements with conservation and cancer specificity reveals correlations with expression and survival.

Hornshøj H et al.

Npj Genomic Medicine, 2018

29354286 (PubMed )
Supplement: 41525_2017_40_MOESM2_ESM.xlsx › ST6

CDK4 protein is degraded by anaphase-promoting complex/cyclosome in mitosis and reaccumulates in early G1 phase to initiate a new cell cycle in HeLa cells.

Chen H et al.

The Journal of Biological Chemistry, 2017

EZH2 alterations in follicular lymphoma: biological and clinical correlations.

Huet S et al.

Blood Cancer Journal, 2017

28430172 (PubMed )
Supplement: bcj201732x5.xlsx › genes_down

Metabolic/Proteomic Signature Defines Two Glioblastoma Subtypes With Different Clinical Outcome.

Marziali G et al.

Scientific Reports, 2016

26857460 (PubMed )
Supplement: srep21557-s1.pdf

Raf/ERK drives the proliferative and invasive phenotype of BMPR2-silenced pulmonary artery endothelial cells.

Awad KS et al.

American Journal of Physiology. Lung Cellular and Molecular Physiology, 2016

26589479 (PubMed )
Supplement: supplemental_table2.xlsx › siBMPR2_phenotype

Consequence of the tumor-associated conversion to cyclin D1b.

Augello MA et al.

Embo Molecular Medicine, 2015

Cyclin D1-Cdk4 controls glucose metabolism independently of cell cycle progression.

Lee Y et al.

Nature, 2014

Cyclin-dependent kinase 4 may be expressed as multiple proteins and have functions that are independent of binding to CCND and RB and occur at the S and G 2/M phases of the cell cycle.

Sun Y et al.

Cell Cycle (georgetown, Tex.), 2013

Basic anatomy and tumor biology of the RPS6KA6 gene that encodes the p90 ribosomal S6 kinase-4.

Sun Y et al.

Oncogene, 2013

A function for cyclin D1 in DNA repair uncovered by protein interactome analyses in human cancers.

Jirawatnotai S et al.

Nature, 2011

Complex alternative splicing of the smarca2 gene suggests the importance of smarca2-B variants.

Yang M et al.

Journal of Cancer, 2011

Cyclins, Cdks, E2f, Skp2, and more at the first international RB Tumor Suppressor Meeting.

Bremner R et al.

Cancer Research, 2010

Cyclin D1b is aberrantly regulated in response to therapeutic challenge and promotes resistance to estrogen antagonists.

Wang Y et al.

Cancer Research, 2008

The LxCxE pRb interaction domain of cyclin D1 is dispensable for murine development.

Landis MW et al.

Cancer Research, 2007

Kinase-independent function of cyclin E.

Geng Y et al.

Molecular Cell, 2007

Requirement for CDK4 kinase function in breast cancer.

Yu Q et al.

Cancer Cell, 2006

Negative regulation of TSC1-TSC2 by mammalian D-type cyclins.

Zacharek SJ et al.

Cancer Research, 2005

Linking cyclins to transcriptional control.

Coqueret O

Gene, 2002

Distinct initiation and maintenance mechanisms cooperate to induce G1 cell cycle arrest in response to DNA damage.

Agami R et al.

Cell, 2000

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