Varaico: Literature-Extracted Genetic Variants

Gene:CCND1
Variant:p.K114E
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CCND1

NM_053056.3:p.K114E

Associated Papers

Nuclear focal adhesion kinase induces APC/C activator protein CDH1-mediated cyclin-dependent kinase 4/6 degradation and inhibits melanoma proliferation.

Murphy JM et al.

The Journal of Biological Chemistry, 2022

Tumor suppression by the EGR1, DMP1, ARF, p53, and PTEN Network.

Inoue K et al.

Cancer Investigation, 2018

CDK4 protein is degraded by anaphase-promoting complex/cyclosome in mitosis and reaccumulates in early G1 phase to initiate a new cell cycle in HeLa cells.

Chen H et al.

The Journal of Biological Chemistry, 2017

Alternate cyclin D1 mRNA splicing modulates p27KIP1 binding and cell migration.

Li Z et al.

The Journal of Biological Chemistry, 2008

Somatic cell type specific gene transfer reveals a tumor-promoting function for p21(Waf1/Cip1).

Liu Y et al.

The Embo Journal, 2007

Identification of mutations that disrupt phosphorylation-dependent nuclear export of cyclin D1.

Benzeno S et al.

Oncogene, 2006

A central domain of cyclin D1 mediates nuclear receptor corepressor activity.

Petre-Draviam CE et al.

Oncogene, 2005

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."