Varaico: Literature-Extracted Genetic Variants

Gene:CCR5
Variant:p.I9T
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CCR5

NM_001394783.1:p.I9T

Associated Papers

Two HIV-1 variants resistant to small molecule CCR5 inhibitors differ in how they use CCR5 for entry.

Berro R et al.

Plos Pathogens, 2009

Structural basis for the interaction of CCR5 with a small molecule, functionally selective CCR5 agonist.

Saita Y et al.

Journal of Immunology (baltimore, Md. : 1950), 2006

The differential sensitivity of human and rhesus macaque CCR5 to small-molecule inhibitors of human immunodeficiency virus type 1 entry is explained by a single amino acid difference and suggests a mechanism of action for these inhibitors.

Billick E et al.

Journal of Virology, 2004

A critical site in the core of the CCR5 chemokine receptor required for binding and infectivity of human immunodeficiency virus type 1.

Siciliano SJ et al.

The Journal of Biological Chemistry, 1999

Polymorphisms in the CCR5 genes of African green monkeys and mice implicate specific amino acids in infections by simian and human immunodeficiency viruses.

Kuhmann SE et al.

Journal of Virology, 1997

Parallel evolution of CCR5-null phenotypes in humans and in a natural host of simian immunodeficiency virus.

Palacios E et al.

Current Biology : Cb, 0

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."