Associated Papers
Elucidating a key anti-HIV-1 and cancer-associated axis: the structure of CCL5 (Rantes) in complex with CCR5.
Tamamis P et al.
Scientific Reports, 2014
Macrophage-tropic HIV-1 variants from brain demonstrate alterations in the way gp120 engages both CD4 and CCR5.
Salimi H et al.
Journal of Leukocyte Biology, 2013
Clinical resistance to vicriviroc through adaptive V3 loop mutations in HIV-1 subtype D gp120 that alter interactions with the N-terminus and ECL2 of CCR5.
Ogert RA et al.
Virology, 2010
Structure-function analysis of human immunodeficiency virus type 1 gp120 amino acid mutations associated with resistance to the CCR5 coreceptor antagonist vicriviroc.
Ogert RA et al.
Journal of Virology, 2009
Two HIV-1 variants resistant to small molecule CCR5 inhibitors differ in how they use CCR5 for entry.
Berro R et al.
Plos Pathogens, 2009
Involvement of the second extracellular loop and transmembrane residues of CCR5 in inhibitor binding and HIV-1 fusion: insights into the mechanism of allosteric inhibition.
Maeda K et al.
Journal of Molecular Biology, 2008
Structural and molecular interactions of CCR5 inhibitors with CCR5.
Maeda K et al.
The Journal of Biological Chemistry, 2006
Contrasting use of CCR5 structural determinants by R5 and R5X4 variants within a human immunodeficiency virus type 1 primary isolate quasispecies.
Yi Y et al.
Journal of Virology, 2003
Molecular anatomy of CCR5 engagement by physiologic and viral chemokines and HIV-1 envelope glycoproteins: differences in primary structural requirements for RANTES, MIP-1 alpha, and vMIP-II Binding.
Navenot JM et al.
Journal of Molecular Biology, 2001
Multiple charged and aromatic residues in CCR5 amino-terminal domain are involved in high affinity binding of both chemokines and HIV-1 Env protein.
Blanpain C et al.
The Journal of Biological Chemistry, 1999
CCR5-Mediated human immunodeficiency virus entry depends on an amino-terminal gp120-binding site and on the conformational integrity of all four extracellular domains.
Genoud S et al.
Journal of Virology, 1999
Amino-terminal substitutions in the CCR5 coreceptor impair gp120 binding and human immunodeficiency virus type 1 entry.
Dragic T et al.
Journal of Virology, 1998
Two distinct CCR5 domains can mediate coreceptor usage by human immunodeficiency virus type 1.
Doranz BJ et al.
Journal of Virology, 1997
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