Varaico: Literature-Extracted Genetic Variants

Gene:CCR5
Variant:p.I42F
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CCR5

NM_001394783.1:p.I42F

Associated Papers

Amino- and Carboxyl-Terminal CCR5 Mutations in Brazilian HIV-1-Infected Women and Homology Model of p.L55Q CCR5 Mutant.

Costa GC et al.

Aids Research and Human Retroviruses, 2015

Inactivating mutations of G protein-coupled receptors and diseases: structure-function insights and therapeutic implications.

Tao YX

Pharmacology & Therapeutics, 2006

Variants of CCR5, which are permissive for HIV-1 infection, show distinct functional responses to CCL3, CCL4 and CCL5.

Dong HF et al.

Genes and Immunity, 2005

The differential sensitivity of human and rhesus macaque CCR5 to small-molecule inhibitors of human immunodeficiency virus type 1 entry is explained by a single amino acid difference and suggests a mechanism of action for these inhibitors.

Billick E et al.

Journal of Virology, 2004

Multiple nonfunctional alleles of CCR5 are frequent in various human populations.

Blanpain C et al.

Blood, 2000

Sequence evolution of the CCR5 chemokine receptor gene in primates.

Zhang YW et al.

Molecular Biology and Evolution, 1999

Naturally occurring CCR5 extracellular and transmembrane domain variants affect HIV-1 Co-receptor and ligand binding function.

Howard OM et al.

The Journal of Biological Chemistry, 1999

Genetics of HIV-1 infection: chemokine receptor CCR5 polymorphism and its consequences.

Carrington M et al.

Human Molecular Genetics, 1999

Novel alleles of the chemokine-receptor gene CCR5.

Carrington M et al.

American Journal of Human Genetics, 1997

Association of the CCR5Δ32 Mutant Genotype with Sickle Cell Disease in Egyptian Patients.

El Sissy MH et al.

Hemoglobin, 0

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."