Varaico: Literature-Extracted Genetic Variants

Gene:CCR5
Variant:p.L104F
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CCR5

NM_001394783.1:p.L104F

Associated Papers

Elucidating a key anti-HIV-1 and cancer-associated axis: the structure of CCL5 (Rantes) in complex with CCR5.

Tamamis P et al.

Scientific Reports, 2014

Allosteric model of maraviroc binding to CC chemokine receptor 5 (CCR5).

Garcia-Perez J et al.

The Journal of Biological Chemistry, 2011

The core domain of chemokines binds CCR5 extracellular domains while their amino terminus interacts with the transmembrane helix bundle.

Blanpain C et al.

The Journal of Biological Chemistry, 2003

Activation of CCR5 by chemokines involves an aromatic cluster between transmembrane helices 2 and 3.

Govaerts C et al.

The Journal of Biological Chemistry, 2003

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."