Varaico: Literature-Extracted Genetic Variants

Gene:CDA
Variant:p.T145T
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CDA

NM_001785.3:p.T145T

Associated Papers

Genetic polymorphisms as potential pharmacogenetic biomarkers for platinum-based chemotherapy in non-small cell lung cancer.

Sito H et al.

Molecular Biology Reports, 2024

Effect of donor GSTM3 rs7483 genetic variant on tacrolimus elimination in the early period after liver transplantation.

Zhang T et al.

Peerj, 2024

39465171 (PubMed )
Supplement: peerj-12-18360-s002.7z › drug-metabolizing_enzymes_and_transporter__DMET__microarray › markerlist.xlsx › markerlist.TXT

Association of Single-Nucleotide Polymorphisms in Capecitabine Bioactivation Pathway with Adjuvant Therapy Safety in Colorectal Cancer Patients.

Cura Y et al.

Pharmaceutics, 2023

Review of genetic and pharmacogenetic differences in cytotoxic and targeted therapies for pancreatic cancer in African Americans.

Telisnor G et al.

Journal of the National Medical Association, 2023

Influence of Single-Nucleotide Polymorphisms on Clinical Outcomes of Capecitabine-Based Chemotherapy in Colorectal Cancer Patients: A Systematic Review.

Cura Y et al.

Cancers, 2023

Pharmacogenomic-guided dosing of fluoropyrimidines beyond DPYD: time for a polygenic algorithm?

Maslarinou A et al.

Frontiers in Pharmacology, 2023

Role of Genetic Polymorphisms in Drug-Metabolizing Enzyme-Mediated Toxicity and Pharmacokinetic Resistance to Anti-Cancer Agents: A Review on the Pharmacogenomics Aspect.

Narendra G et al.

Clinical Pharmacokinetics, 2022

Role of Pharmacogenetics in the Treatment of Acute Myeloid Leukemia: Systematic Review and Future Perspectives.

Pinto-Merino Á et al.

Pharmaceutics, 2022

Comprehensive analysis of important pharmacogenes in Koreans using the DMET™ platform.

Kim B et al.

Translational and Clinical Pharmacology, 2021

34621706 (PubMed )
Supplement: tcp-29-135-s001.xls › tcp-29-135-s001

Cytidine deaminase 435C>T polymorphism relates to gemcitabine-platinum efficacy and hematological toxicity in Chinese non-small-cell lung cancer patients.

Hu L et al.

Neoplasma, 2021

Severe toxicity of capecitabine in a patient with DPD deficiency after a safe FEC-100 experience: why we should test DPD deficiency in all patients before high-dose fluoropyrimidines.

Maillard M et al.

Cancer Chemotherapy and Pharmacology, 2021

Whole genome mapping and identification of single nucleotide polymorphisms of four Bangladeshi individuals and their functional significance.

Khan S et al.

Bmc Research Notes, 2021

33743798 (PubMed )
Supplement: 13104_2021_5514_MOESM4_ESM.zip › Supplementary_File_1A-1.xlsx › Supplementary_File_1A-1.exonic_

Decoding variants in drug-metabolizing enzymes and transporters in solid tumor patients by whole-exome sequencing.

Aboul-Soud MAM et al.

Saudi Journal of Biological Sciences, 2021

33424349 (PubMed )
Supplement: mmc1.xlsx › Sheet1

Targeted next generation sequencing as a tool for precision medicine.

Gulilat M et al.

Bmc Medical Genomics, 2019

31159795 (PubMed )
Supplement: 12920_2019_527_MOESM1_ESM.xlsx › Table_S6

Determinants of the interindividual variability in serum cytidine deaminase activity of patients with solid tumours.

Cohen R et al.

British Journal of Clinical Pharmacology, 2019

Host genetic profiling to increase drug safety in colorectal cancer from discovery to implementation.

Cecchin E et al.

Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy, 2018

Severe acute toxicity following gemcitabine administration: A report of four cases with cytidine deaminase polymorphisms evaluation.

Hryciuk B et al.

Oncology Letters, 2018

Novel Genetic Variants in Carboxylesterase 1 Predict Severe Early-Onset Capecitabine-Related Toxicity.

Hamzic S et al.

Clinical Pharmacology and Therapeutics, 2017

The chronological sequence of somatic mutations in early gastric carcinogenesis inferred from multiregion sequencing of gastric adenomas.

Lim CH et al.

Oncotarget, 2016

27175599 (PubMed )
Supplement: oncotarget-07-39758-s006.xlsx › TableS5

The influence of cytidine deaminase -33delC polymorphism on treatment outcome with high-dose cytarabine in Chinese patients with relapsed acute myeloid leukaemia.

He H et al.

Journal of Clinical Pharmacy and Therapeutics, 2015

Role of cytidine deaminase in toxicity and efficacy of nucleosidic analogs.

Serdjebi C et al.

Expert Opinion on Drug Metabolism & Toxicology, 2015

Cytidine deaminase polymorphism predicts toxicity of gemcitabine-based chemotherapy.

Ding X et al.

Gene, 2015

Cytidine Deaminase as a Molecular Predictor of Gemcitabine Response in Patients with Biliary Tract Cancer.

Yoon KA et al.

Oncology, 2015

Potentially functional SNPs (pfSNPs) as novel genomic predictors of 5-FU response in metastatic colorectal cancer patients.

Wang J et al.

Plos One, 2014

25372392 (PubMed )
Supplement: pone.0111694.s006.pdf

Determination of common genetic variants in cytidine deaminase (CDA) gene in Indian ethnic population.

Iyer SN et al.

Gene, 2013

Association of cytidine deaminase and xeroderma pigmentosum group D polymorphisms with response, toxicity, and survival in cisplatin/gemcitabine-treated advanced non-small cell lung cancer patients.

Ludovini V et al.

Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer, 2011

Ethnic differences in the metabolism, toxicology and efficacy of three anticancer drugs.

Sai K et al.

Expert Opinion on Drug Metabolism & Toxicology, 2011

High-resolution melting analysis of sequence variations in the cytidine deaminase gene (CDA) in patients with cancer treated with gemcitabine.

Raynal C et al.

Therapeutic Drug Monitoring, 2010

Distribution of gemcitabine pathway genotypes in ethnic Asians and their association with outcome in non-small cell lung cancer patients.

Soo RA et al.

Lung Cancer (amsterdam, Netherlands), 2009

Pharmacogenetics in breast cancer therapy.

Tan SH et al.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research, 2008

Toxic death case in a patient undergoing gemcitabine-based chemotherapy in relation with cytidine deaminase downregulation.

Mercier C et al.

Pharmacogenetics and Genomics, 2007

Severe drug toxicity associated with a single-nucleotide polymorphism of the cytidine deaminase gene in a Japanese cancer patient treated with gemcitabine plus cisplatin.

Yonemori K et al.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research, 2005

Identification and analysis of single-nucleotide polymorphisms in the gemcitabine pharmacologic pathway.

Fukunaga AK et al.

The Pharmacogenomics Journal, 2004

Gemcitabine and platinum pathway pharmacogenetics in Asian breast cancer patients.

Wong AL et al.

Cancer Genomics & Proteomics, 0

The impact of CDA A79C gene polymorphisms on the response and hematologic toxicity in gemcitabine-treated patients: a meta-analysis.

Li H et al.

The International Journal of Biological Markers, 0

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."