Varaico: Literature-Extracted Genetic Variants

Gene:CDC25C
Variant:p.S216A
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CDC25C

NM_001790.5:p.S216A

Associated Papers

Structural basis for recruitment of the CHK1 DNA damage kinase by the CLASPIN scaffold protein.

Day M et al.

Structure (london, England : 1993), 2021

Recurrent CDC25C mutations drive malignant transformation in FPD/AML.

Yoshimi A et al.

Nature Communications, 2014

ATM/ATR checkpoint activation downregulates CDC25C to prevent mitotic entry with uncapped telomeres.

Thanasoula M et al.

The Embo Journal, 2012

Cyclin E deregulation impairs mitotic progression through premature activation of Cdc25C.

Bagheri-Yarmand R et al.

Cancer Research, 2010

p14ARF triggers G2 arrest through ERK-mediated Cdc25C phosphorylation, ubiquitination and proteasomal degradation.

Eymin B et al.

Cell Cycle (georgetown, Tex.), 2006

G2 checkpoint abrogators as anticancer drugs.

Kawabe T

Molecular Cancer Therapeutics, 2004

Functional analysis of C-TAK1 substrate binding and identification of PKP2 as a new C-TAK1 substrate.

Müller J et al.

The Embo Journal, 2003

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."