Associated Papers
A lipidation inhibitor rescues impaired neurite outgrowth caused by the CDC42 mutation associated with Takenouchi-Kosaki syndrome in Neuro2A cells.
Daimon E et al.
Brain & Development, 2026
MICAL1 activation by PAK1 mediates actin filament disassembly.
McGarry DJ et al.
Cell Reports, 2022
CDC42-IQGAP Interactions Scrutinized: New Insights into the Binding Properties of the GAP-Related Domain.
Mosaddeghzadeh N et al.
International Journal of Molecular Sciences, 2022
Molecular dynamics simulations reveal the activation mechanism of mutations G12V and Q61L of Cdc42.
Chen S et al.
Proteins, 2022
Macrothrombocytopenia of Takenouchi-Kosaki syndrome is ameliorated by CDC42 specific- and lipidation inhibitors in MEG-01 cells.
Daimon E et al.
Scientific Reports, 2021
Loss-of-Function Mutations in TRAF7 and KLF4 Cooperatively Activate RAS-Like GTPase Signaling and Promote Meningioma Development.
Najm P et al.
Cancer Research, 2021
Active and Inactive Cdc42 Differ in Their Insert Region Conformational Dynamics.
Haspel N et al.
Biophysical Journal, 2021
Roles of the PH, coiled-coil and SAM domains of the yeast polarity protein Boi2 in polarity-site localization and function in polarized growth.
Jia ZW et al.
Current Genetics, 2020
Robo2 regulates synaptic oxytocin content by affecting actin dynamics.
Anbalagan S et al.
Elife, 2019
Overexpression of CDC42SE1 in A431 Cells Reduced Cell Proliferation by Inhibiting the Akt Pathway.
Kalailingam P et al.
Cells, 2019
LowMACA: exploiting protein family analysis for the identification of rare driver mutations in cancer.
Melloni GE et al.
Bmc Bioinformatics, 2016
Control of polarized growth by the Rho family GTPase Rho4 in budding yeast: requirement of the N-terminal extension of Rho4 and regulation by the Rho GTPase-activating protein Bem2.
Gong T et al.
Eukaryotic Cell, 2013
Novel split-luciferase-based genetically encoded biosensors for noninvasive visualization of Rho GTPases.
Leng W et al.
Plos One, 2013
Structural insights into formation of an active signaling complex between Rac and phospholipase C gamma 2.
Bunney TD et al.
Molecular Cell, 2009
Activation of the Cdc42p GTPase by cyclin-dependent protein kinases in budding yeast.
Sopko R et al.
The Embo Journal, 2007
Stimulation of actin polymerization by vacuoles via Cdc42p-dependent signaling.
Isgandarova S et al.
The Journal of Biological Chemistry, 2007
Separate membrane targeting and anchoring domains function in the localization of the S. cerevisiae Cdc24p guanine nucleotide exchange factor.
Toenjes KA et al.
Current Genetics, 2004
Insulin-like growth factor-I diminishes the activation status and expression of the small GTPase Cdc42 in articular chondrocytes.
Fortier LA et al.
Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society, 2004
The regulation of actin remodeling during T-cell-APC conjugate formation.
Cannon JL et al.
Immunological Reviews, 2002
The Cdc42p GTPase is involved in a G2/M morphogenetic checkpoint regulating the apical-isotropic switch and nuclear division in yeast.
Richman TJ et al.
The Journal of Biological Chemistry, 1999
The human WASP-interacting protein, WIP, activates the cell polarity pathway in yeast.
Vaduva G et al.
The Journal of Biological Chemistry, 1999
Cdc42: An essential Rho-type GTPase controlling eukaryotic cell polarity.
Johnson DI
Microbiology and Molecular Biology Reviews : Mmbr, 1999
Interaction of Bnr1p with a novel Src homology 3 domain-containing Hof1p. Implication in cytokinesis in Saccharomyces cerevisiae.
Kamei T et al.
The Journal of Biological Chemistry, 1998
The Cdc42p effector Gic2p is targeted for ubiquitin-dependent degradation by the SCFGrr1 complex.
Jaquenoud M et al.
The Embo Journal, 1998
Analysis of the mechanisms of action of the Saccharomyces cerevisiae dominant lethal cdc42G12V and dominant negative cdc42D118A mutations.
Davis CR et al.
The Journal of Biological Chemistry, 1998
Novel Cdc42-binding proteins Gic1 and Gic2 control cell polarity in yeast.
Brown JL et al.
Genes & Development, 1997
Characterization of the Saccharomyces cerevisiae cdc42-1ts allele and new temperature-conditional-lethal cdc42 alleles.
Miller PJ et al.
Yeast (chichester, England), 1997
The yeast phosphatidylinositol kinase homolog TOR2 activates RHO1 and RHO2 via the exchange factor ROM2.
Schmidt A et al.
Cell, 1997
A mechanism of Bud1p GTPase action suggested by mutational analysis and immunolocalization.
Michelitch M et al.
Current Biology : Cb, 1996
Cdc42p GTPase is involved in controlling polarized cell growth in Schizosaccharomyces pombe.
Miller PJ et al.
Molecular and Cellular Biology, 1994