Associated Papers
The brain-specific splice variant of the CDC42 GTPase works together with the kinase ACK to downregulate the EGF receptor in promoting neurogenesis.
Endo M et al.
The Journal of Biological Chemistry, 2022
The two splice variant forms of Cdc42 exert distinct and essential functions in neurogenesis.
Endo M et al.
The Journal of Biological Chemistry, 2020
Rho GTPases, their post-translational modifications, disease-associated mutations and pharmacological inhibitors.
Olson MF
Small Gtpases, 2018
CDC42 is required for epicardial and pro-epicardial development by mediating FGF receptor trafficking to the plasma membrane.
Li J et al.
Development (cambridge, England), 2017
Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma.
Krauthammer M et al.
Nature Genetics, 2012
22842228 (PubMed )
Supplement: NIHMS390374-supplement-1.pdf
C-terminal di-arginine motif of Cdc42 protein is essential for binding to phosphatidylinositol 4,5-bisphosphate-containing membranes and inducing cellular transformation.
Johnson JL et al.
The Journal of Biological Chemistry, 2012
Glioblastoma motility occurs in the absence of actin polymer.
Panopoulos A et al.
Molecular Biology of the Cell, 2011
Backbone dynamics of an oncogenic mutant of Cdc42Hs shows increased flexibility at the nucleotide-binding site.
Adams PD et al.
Biochemistry, 2004
Cdc42: An essential Rho-type GTPase controlling eukaryotic cell polarity.
Johnson DI
Microbiology and Molecular Biology Reviews : Mmbr, 1999
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