Varaico: Literature-Extracted Genetic Variants

Gene:CDC42
Variant:p.C188S
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CDC42

NM_001791.4:p.C188S

Associated Papers

The GTPase-activating protein Rga1 interacts with Rho3 GTPase and may regulate its function in polarized growth in budding yeast.

He F et al.

Plos One, 2015

Essential role of the NH2-terminal region of Cdc24 guanine nucleotide exchange factor in its initial polarized localization in Saccharomyces cerevisiae.

Fujimura-Kamada K et al.

Eukaryotic Cell, 2012

Release of autoinhibition of ASEF by APC leads to CDC42 activation and tumor suppression.

Mitin N et al.

Nature Structural & Molecular Biology, 2007

Genetic analysis of the interface between Cdc42p and the CRIB domain of Ste20p in Saccharomyces cerevisiae.

Ash J et al.

Genetics, 2003

The Cdc42p GTPase is involved in a G2/M morphogenetic checkpoint regulating the apical-isotropic switch and nuclear division in yeast.

Richman TJ et al.

The Journal of Biological Chemistry, 1999

Cdc42: An essential Rho-type GTPase controlling eukaryotic cell polarity.

Johnson DI

Microbiology and Molecular Biology Reviews : Mmbr, 1999

Analysis of the mechanisms of action of the Saccharomyces cerevisiae dominant lethal cdc42G12V and dominant negative cdc42D118A mutations.

Davis CR et al.

The Journal of Biological Chemistry, 1998

The yeast phosphatidylinositol kinase homolog TOR2 activates RHO1 and RHO2 via the exchange factor ROM2.

Schmidt A et al.

Cell, 1997

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."