Associated Papers
Integrating evidence from protein domains to identify cancer driver mutations.
Ostroverkhova D et al.
Protein Science : a Publication of the Protein Society, 2026
41556616 (PubMed )
Supplement: PRO-35-e70422-s002.xlsx › Table_S1
DNA2 protein destruction dictates DNA hyperexcision, cGAS-STING activation, and innate immune response in CDK12-deregulated cancers.
Sun R et al.
Proceedings of the National Academy of Sciences of the United States of America, 2025
40623188 (PubMed )
Supplement: pnas.2413732122.sapp.pdf
Landscape of drug-resistance mutations in kinase regulatory hotspots.
Kim P et al.
Briefings in Bioinformatics, 2021
Targeted Therapy of Papillary Thyroid Cancer: A Comprehensive Genomic Analysis.
Hescheler DA et al.
Frontiers in Endocrinology, 2021
34630336 (PubMed )
Supplement: Table_1.xlsx › Tab2
CDK12 regulates DNA repair genes by suppressing intronic polyadenylation.
Dubbury SJ et al.
Nature, 2018
Copy number signatures and mutational processes in ovarian carcinoma.
Macintyre G et al.
Nature Genetics, 2018
30104763 (PubMed )
Supplement: NIHMS78219-supplement-3.xlsx › mutated_cases
Pan-cancer analysis of bi-allelic alterations in homologous recombination DNA repair genes.
Riaz N et al.
Nature Communications, 2017
29021619 (PubMed )
Supplement: 41467_2017_921_MOESM5_ESM.xlsx › Sheet1
CDK12 regulates alternative last exon mRNA splicing and promotes breast cancer cell invasion.
Tien JF et al.
Nucleic Acids Research, 2017
28334900 (PubMed )
Supplement: gkx187_Supp.zip › nar-01703-a-2016-File011.pdf
Identification and analysis of mutational hotspots in oncogenes and tumour suppressors.
Baeissa H et al.
Oncotarget, 2017
Role and therapeutic potential of CDK12 in human cancers.
Chilà R et al.
Cancer Treatment Reviews, 2016
Ovarian Cancers Harboring Inactivating Mutations in CDK12 Display a Distinct Genomic Instability Pattern Characterized by Large Tandem Duplications.
Popova T et al.
Cancer Research, 2016
26787835 (PubMed )
Supplement: 00085472can152128-sup-152923_2_supp_3283923_nztpsz.pdf
Functional annotation of rare gene aberration drivers of pancreatic cancer.
Tsang YH et al.
Nature Communications, 2016
26806015 (PubMed )
Supplement: ncomms10500-s2.xls › Sheet1
Ovarian carcinoma CDK12 mutations misregulate expression of DNA repair genes via deficient formation and function of the Cdk12/CycK complex.
Ekumi KM et al.
Nucleic Acids Research, 2015
Genome-wide profiling of genetic synthetic lethality identifies CDK12 as a novel determinant of PARP1/2 inhibitor sensitivity.
Bajrami I et al.
Cancer Research, 2014
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