Varaico: Literature-Extracted Genetic Variants

Gene:CDK2
Variant:p.Y15F
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CDK2

NM_001798.5:p.Y15F

Associated Papers

Discriminating activating, deactivating and resistance variants in protein kinases.

Singh G et al.

Genome Medicine, 2025

41152984 (PubMed )
Supplement: 13073_2025_1564_MOESM2_ESM.xlsx › Table_S5

Intra-S phase checkpoint kinase Chk1 dissociates replication proteins Treslin and TopBP1 through multiple mechanisms during replication stress.

Kelly RL et al.

The Journal of Biological Chemistry, 2022

D3DistalMutation: a Database to Explore the Effect of Distal Mutations on Enzyme Activity.

Wang X et al.

Journal of Chemical Information and Modeling, 2021

Human DDK rescues stalled forks and counteracts checkpoint inhibition at unfired origins to complete DNA replication.

Jones MJK et al.

Molecular Cell, 2021

CDK2 kinase activity is a regulator of male germ cell fate.

Singh P et al.

Development (cambridge, England), 2019

Chfr acts with the p38 stress kinases to block entry to mitosis in mammalian cells.

Matsusaka T et al.

The Journal of Cell Biology, 2004

Activation and inhibition of cyclin-dependent kinase-2 by phosphorylation; a molecular dynamics study reveals the functional importance of the glycine-rich loop.

Bártová I et al.

Protein Science : a Publication of the Protein Society, 2004

Differential contribution of inhibitory phosphorylation of CDC2 and CDK2 for unperturbed cell cycle control and DNA integrity checkpoints.

Chow JP et al.

The Journal of Biological Chemistry, 2003

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."