Varaico: Literature-Extracted Genetic Variants

Gene:CDK2
Variant:p.D145N
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CDK2

NM_001798.5:p.D145N

Associated Papers

Targeting G1-S-checkpoint-compromised cancers with cyclin A/B RxL inhibitors.

Singh S et al.

Nature, 2025

40836083 (PubMed )
Supplement: 41586_2025_9433_MOESM4_ESM.zip › 2024-07-15654B-s4 › Table_S5_052925.xlsx › Tab_8-zscore_CDK2_C_T

Cyclin-dependent protein kinases and cell cycle regulation in biology and disease.

Pellarin I et al.

Signal Transduction and Targeted Therapy, 2025

A Huluwa phosphorylation switch regulates embryonic axis induction.

Li Y et al.

Nature Communications, 2024

Phenotypical microRNA screen reveals a noncanonical role of CDK2 in regulating neutrophil migration.

Hsu AY et al.

Proceedings of the National Academy of Sciences of the United States of America, 2019

Biosynthesis and genetic encoding of phosphothreonine through parallel selection and deep sequencing.

Zhang MS et al.

Nature Methods, 2017

CDK2 phosphorylation regulates the protein stability of KLF10 by interfering with binding of the E3 ligase SIAH1.

Lin CH et al.

Biochimica Et Biophysica Acta, 2015

A critical role of CDKN3 in Bcr-Abl-mediated tumorigenesis.

Chen Q et al.

Plos One, 2014

p73 suppresses polyploidy and aneuploidy in the absence of functional p53.

Talos F et al.

Molecular Cell, 2007

Spy1 enhances phosphorylation and degradation of the cell cycle inhibitor p27.

McAndrew CW et al.

Cell Cycle (georgetown, Tex.), 2007

A novel Cdk2 interactor is phosphorylated by Cdc7 and associates with components of the replication complexes.

Grishina I et al.

Cell Cycle (georgetown, Tex.), 2005

Molecular dissection of the interaction between p27 and Kip1 ubiquitylation-promoting complex, the ubiquitin ligase that regulates proteolysis of p27 in G1 phase.

Kotoshiba S et al.

The Journal of Biological Chemistry, 2005

Expression of cyclin E renders cyclin D-CDK4 dispensable for inactivation of the retinoblastoma tumor suppressor protein, activation of E2F, and G1-S phase progression.

Keenan SM et al.

The Journal of Biological Chemistry, 2004

T-loop phosphorylation stabilizes the CDK7-cyclin H-MAT1 complex in vivo and regulates its CTD kinase activity.

Larochelle S et al.

The Embo Journal, 2001

Targeted disruption of Skp2 results in accumulation of cyclin E and p27(Kip1), polyploidy and centrosome overduplication.

Nakayama K et al.

The Embo Journal, 2000

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."