Associated Papers
CDK4 inactivation inhibits apoptosis via mitochondria-ER contact remodeling in triple-negative breast cancer.
Ziegler DV et al.
Nature Communications, 2025
Tumor regression and resistance mechanisms upon CDK4 and RAF1 inactivation in KRAS/P53 mutant lung adenocarcinomas.
Esteban-Burgos L et al.
Proceedings of the National Academy of Sciences of the United States of America, 2020
Complete Regression of Advanced Pancreatic Ductal Adenocarcinomas upon Combined Inhibition of EGFR and C-RAF.
Blasco MT et al.
Cancer Cell, 2019
Senescence-associated ribosome biogenesis defects contributes to cell cycle arrest through the Rb pathway.
Lessard F et al.
Nature Cell Biology, 2018
Nuclear cyclin D1/CDK4 kinase regulates CUL4 expression and triggers neoplastic growth via activation of the PRMT5 methyltransferase.
Aggarwal P et al.
Cancer Cell, 2010
The cyclin D1-dependent kinase associates with the pre-replication complex and modulates RB.MCM7 binding.
Gladden AB et al.
The Journal of Biological Chemistry, 2003
Cyclin E2, a novel human G1 cyclin and activating partner of CDK2 and CDK3, is induced by viral oncoproteins.
Zariwala M et al.
Oncogene, 1998
Mutual requirement of CDK4 and Myc in malignant transformation: evidence for cyclin D1/CDK4 and p16INK4A as upstream regulators of Myc.
Haas K et al.
Oncogene, 1997
Regulation of cell cycle entry and G1 progression by CSF-1.
Roussel MF
Molecular Reproduction and Development, 1997
Direct binding of cyclin D to the retinoblastoma gene product (pRb) and pRb phosphorylation by the cyclin D-dependent kinase CDK4.
Kato J et al.
Genes & Development, 1993
Ribosomal protein RPL22/eL22 regulates the cell cycle by acting as an inhibitor of the CDK4-cyclin D complex.
Del Toro N et al.
Cell Cycle (georgetown, Tex.), 0
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