Associated Papers
Altered expression and mutations in cell cycle genes CCND1, CDK4, CDKN2B and TP53 are associated with Pakistani breast cancer patients.
Tariq W et al.
Molecular Biology Reports, 2026
Integrating evidence from protein domains to identify cancer driver mutations.
Ostroverkhova D et al.
Protein Science : a Publication of the Protein Society, 2026
Subclinical fields of BRAF V600E-mutant melanocytes populate human skin and are enriched around melanoma and naevi.
Lee KJ et al.
The British Journal of Dermatology, 2026
Prevalence of germline pathogenic variants in cancer predisposition genes in the Japanese population.
Yamaguchi T et al.
Japanese Journal of Clinical Oncology, 2025
Leveraging oncology clinical case report data through the Cancer Knowledgebase (CKB).
Gokhale RH et al.
Personalized Medicine, 2025
Conjunctival melanoma genomic analysis reveals intermediate tumor mutation burden and genomic overlap with cutaneous melanoma.
Dimitriou F et al.
Npj Precision Oncology, 2025
Discriminating activating, deactivating and resistance variants in protein kinases.
Singh G et al.
Genome Medicine, 2025
A neomorphic protein interface catalyzes covalent inhibition of RASG12D aspartic acid in tumors.
Weller C et al.
Science (new York, N.y.), 2025
Mapping chromatin interactions at melanoma susceptibility loci uncovers distant cis-regulatory gene targets.
Thakur R et al.
American Journal of Human Genetics, 2025
Pan-Cancer Exome-wide analysis of germline mutational patterns and pathways.
Alnaqbi H et al.
Scientific Reports, 2025
Analysis of Variants Induced by Combined Ex Vivo Irradiation and In Vivo Tumorigenesis Suggests a Role for the ZNF831 p.R1393Q Variant in Cutaneous Melanoma Development.
Usoltsev D et al.
The Journal of Investigative Dermatology, 2025
Germline Non-CDKN2A Variants in Melanoma and Associated Hereditary Cancer Syndromes.
Fiasconaro CA et al.
Diseases (basel, Switzerland), 2025
Circulating tumor DNA profiling for non-invasive genomic analysis in Indian lung cancer patients: A real-world experience.
Jha P et al.
The Journal of Liquid Biopsy, 2025
Polygenic Risk Score Analysis of 37 SNPs Associated with Melanoma Risk in Colombian Population.
Tovar-Parra D et al.
International Journal of Molecular Sciences, 2025
CDK4 loss-of-function mutations cause microcephaly and short stature.
Verdu Schlie A et al.
Genes & Development, 2025
The complexity of tobacco smoke-induced mutagenesis in head and neck cancer.
Torrens L et al.
Nature Genetics, 2025
Cdk6's functions are critically regulated by its unique C-terminus.
Schirripa A et al.
Iscience, 2025
Establishment of a human ovarian endometrioid carcinoma cell line by constitutive expression of cyclin-dependent kinase 4, cyclin D1 and telomerase reverse transcriptase.
Hoshino H et al.
Human Cell, 2025
Cyclin-dependent protein kinases and cell cycle regulation in biology and disease.
Pellarin I et al.
Signal Transduction and Targeted Therapy, 2025
CDK4 inactivation inhibits apoptosis via mitochondria-ER contact remodeling in triple-negative breast cancer.
Ziegler DV et al.
Nature Communications, 2025
Genome sequencing enhances the diagnostic yield and expands the genetic landscape of male breast cancer.
Wen W et al.
Genetics in Medicine Open, 2025
Pharmacological targeting of casein kinase 1δ suppresses oncogenic NRAS-driven melanoma.
Wen Y et al.
Nature Communications, 2024
Mapping chromatin interactions at melanoma susceptibility loci and cell-type specific dataset integration uncovers distant gene targets of cis-regulation.
Thakur R et al.
Medrxiv : the Preprint Server for Health Sciences, 2024
Aurora B inhibitors promote RB hypophosphorylation and senescence independent of p53-dependent CDK2/4 inhibition.
Vora S et al.
Cell Death & Disease, 2024
An attractor state zone precedes neural crest fate in melanoma initiation.
McConnell AM et al.
Biorxiv : the Preprint Server for Biology, 2024
Loss of p14 diminishes immunogenicity in melanoma via non-canonical Wnt signaling by reducing the peptide surface density.
Wohlfarth J et al.
Molecular Oncology, 2024
Transcriptome-wide profiling for melanocytes derived from newborn and adult human epidermis with enhanced proliferation.
Orimoto A et al.
Cell Biology International, 2024
Impact of protein and small molecule interactions on kinase conformations.
Kugler V et al.
Elife, 2024
Multiple Endocrine Neoplasia Type 1 Regulates TGFβ-Mediated Suppression of Tumor Formation and Metastasis in Melanoma.
Boudreault J et al.
Cells, 2024
Transactivation of Met signaling by oncogenic Gnaq drives the evolution of melanoma in Hgf-Cdk4 mice.
Mengoni M et al.
Cancer Gene Therapy, 2024
Evaluation of ARID1A as a Potential Biomarker for Predicting Response to Immune Checkpoint Inhibitors in Patients with Endometrial Cancer.
Yamashita H et al.
Cancers, 2024
Proteomic characterization of human LMNA-related congenital muscular dystrophy muscle cells.
Storey EC et al.
Neuromuscular Disorders : Nmd, 2024
Association between KRAS and PIK3CA Mutations and Progesterone Resistance in Endometriotic Epithelial Cell Line.
Kanno K et al.
Current Issues in Molecular Biology, 2024
A multiparameter liquid biopsy approach allows to track melanoma dynamics and identify early treatment resistance.
Scaini MC et al.
Npj Precision Oncology, 2024
CDK6 inhibits de novo lipogenesis in white adipose tissues but not in the liver.
Hu AJ et al.
Nature Communications, 2024
Beyond cell cycle regulation: The pleiotropic function of CDK4 in cancer.
Ziegler DV et al.
Seminars in Cancer Biology, 2024
Loss of RAB25 Cooperates with Oncogenes in the Transformation of Human Mammary Epithelial Cells (HMECs) to Give Rise to Claudin-Low Tumors.
Joshi P et al.
Biomed Research International, 2024
Unveiling the genetic landscape of hereditary melanoma: From susceptibility to surveillance.
Zheng C et al.
Cancer Treatment and Research Communications, 2024
Mining cancer genomes for change-of-metabolic-function mutations.
Tu KJ et al.
Communications Biology, 2023
Integrative analysis reveals early epigenetic alterations in high-grade serous ovarian carcinomas.
Machino H et al.
Experimental & Molecular Medicine, 2023
Noncanonical CDK4 signaling rescues diabetes in a mouse model by promoting β cell differentiation.
Stamateris RE et al.
The Journal of Clinical Investigation, 2023
Deep-penetrating-nevus-like melanoma arising in patients with familial adenomatous polyposis syndrome.
Russell-Goldman E et al.
Journal of Cutaneous Pathology, 2023
Standing in the canine precision medicine knowledge gap: Improving annotation of canine cancer genomic biomarkers through systematic comparative analysis of human cancer mutations in COSMIC.
Sakthikumar S et al.
Veterinary and Comparative Oncology, 2023
CDKN2A/CDK4 status in Brazilian patients meeting clinical criteria for hereditary melanoma: a cross-sectional descriptive trial.
Arnaut JRMB et al.
International Journal of Dermatology, 2023