Varaico: Literature-Extracted Genetic Variants

Gene:CDK6
Variant:p.D163N
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CDK6

NM_001145306.2:p.D163N

Associated Papers

CDK6 activity in a recurring convergent kinase network motif.

Gangemi CG et al.

Faseb Journal : Official Publication of the Federation of American Societies for Experimental Biology, 2023

INK4 Tumor Suppressor Proteins Mediate Resistance to CDK4/6 Kinase Inhibitors.

Li Q et al.

Cancer Discovery, 2022

A cyclin D-CDK6 dimer helps to reshuffle cyclin-dependent kinase inhibitors (CKI) to overcome TGF-beta-mediated arrest and maintain CDK2 activity.

Nataraj SE et al.

Cell Cycle (georgetown, Tex.), 2021

CDK4/6 inhibitors target SMARCA4-determined cyclin D1 deficiency in hypercalcemic small cell carcinoma of the ovary.

Xue Y et al.

Nature Communications, 2019

CDK6 protects epithelial ovarian cancer from platinum-induced death via FOXO3 regulation.

Dall'Acqua A et al.

Embo Molecular Medicine, 2017

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."