Associated Papers
Discriminating activating, deactivating and resistance variants in protein kinases.
Singh G et al.
Genome Medicine, 2025
41152984 (PubMed )
Supplement: 13073_2025_1564_MOESM2_ESM.xlsx › Table_S6
Cdk6's functions are critically regulated by its unique C-terminus.
Schirripa A et al.
Iscience, 2025
Non-canonical CDK6 activity promotes cilia disassembly by suppressing axoneme polyglutamylation.
He K et al.
The Journal of Cell Biology, 2025
Impact of protein and small molecule interactions on kinase conformations.
Kugler V et al.
Elife, 2024
CDK6 activity in a recurring convergent kinase network motif.
Gangemi CG et al.
Faseb Journal : Official Publication of the Federation of American Societies for Experimental Biology, 2023
INK4 Tumor Suppressor Proteins Mediate Resistance to CDK4/6 Kinase Inhibitors.
Li Q et al.
Cancer Discovery, 2022
A cyclin D-CDK6 dimer helps to reshuffle cyclin-dependent kinase inhibitors (CKI) to overcome TGF-beta-mediated arrest and maintain CDK2 activity.
Nataraj SE et al.
Cell Cycle (georgetown, Tex.), 2021
MicroRNA-Mediated Suppression of the TGF-β Pathway Confers Transmissible and Reversible CDK4/6 Inhibitor Resistance.
Cornell L et al.
Cell Reports, 2019
CDK6 protects epithelial ovarian cancer from platinum-induced death via FOXO3 regulation.
Dall'Acqua A et al.
Embo Molecular Medicine, 2017
CDK6 associates with the centrosome during mitosis and is mutated in a large Pakistani family with primary microcephaly.
Hussain MS et al.
Human Molecular Genetics, 2013
CDK6 kinase activity is required for thymocyte development.
Hu MG et al.
Blood, 2011
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