Associated Papers
Discriminating activating, deactivating and resistance variants in protein kinases.
Singh G et al.
Genome Medicine, 2025
41152984 (PubMed )
Supplement: 13073_2025_1564_MOESM2_ESM.xlsx › Table_S5
Structural basis of Cdk7 activation by dual T-loop phosphorylation.
Düster R et al.
Nature Communications, 2024
Structural basis of Cdk7 activation by dual T-loop phosphorylation.
Düster R et al.
Biorxiv : the Preprint Server for Biology, 2024
The cryoelectron microscopy structure of the human CDK-activating kinase.
Greber BJ et al.
Proceedings of the National Academy of Sciences of the United States of America, 2020
CDK7 regulates organ size and tumor growth by safeguarding the Hippo pathway effector Yki/Yap/Taz in the nucleus.
Cho YS et al.
Genes & Development, 2020
Structural basis of TFIIH activation for nucleotide excision repair.
Kokic G et al.
Nature Communications, 2019
Genetic inactivation of Cdk7 leads to cell cycle arrest and induces premature aging due to adult stem cell exhaustion.
Ganuza M et al.
The Embo Journal, 2012
Xpd/Ercc2 regulates CAK activity and mitotic progression.
Chen J et al.
Nature, 2003
T-loop phosphorylation stabilizes the CDK7-cyclin H-MAT1 complex in vivo and regulates its CTD kinase activity.
Larochelle S et al.
The Embo Journal, 2001
Dual phosphorylation of the T-loop in cdk7: its role in controlling cyclin H binding and CAK activity.
Martinez AM et al.
The Embo Journal, 1997
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