Associated Papers
Discriminating activating, deactivating and resistance variants in protein kinases.
Singh G et al.
Genome Medicine, 2025
A precisely positioned MED12 activation helix stimulates CDK8 kinase activity.
Klatt F et al.
Proceedings of the National Academy of Sciences of the United States of America, 2020
De Novo Missense Substitutions in the Gene Encoding CDK8, a Regulator of the Mediator Complex, Cause a Syndromic Developmental Disorder.
Calpena E et al.
American Journal of Human Genetics, 2019
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