Varaico: Literature-Extracted Genetic Variants

Gene:CDK9
Variant:p.T186A
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CDK9

NM_001261.4:p.T186A

Associated Papers

CDK9 interacts with a RanGTP-Importin-β complex to regulate erythroid enucleation.

Newton LM et al.

Journal of Cell Science, 2026

Discriminating activating, deactivating and resistance variants in protein kinases.

Singh G et al.

Genome Medicine, 2025

41152984 (PubMed )
Supplement: 13073_2025_1564_MOESM2_ESM.xlsx › Table_S5

Cyclin-dependent kinase 7 (CDK7)-mediated phosphorylation of the CDK9 activation loop promotes P-TEFb assembly with Tat and proviral HIV reactivation.

Mbonye U et al.

The Journal of Biological Chemistry, 2018

Phosphorylation of CDK9 at Ser175 enhances HIV transcription and is a marker of activated P-TEFb in CD4(+) T lymphocytes.

Mbonye UR et al.

Plos Pathogens, 2013

Mediator MED23 regulates basal transcription in vivo via an interaction with P-TEFb.

Wang W et al.

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."