Associated Papers
Cell cycle duration determines oncogenic transformation capacity.
Chen D et al.
Nature, 2025
Distinct outcomes from targeted perturbations of the multi-subunit SCFSkp2 E3 ubiquitin ligase in blocking Trp53/Rb1-null prostate tumorigenesis.
Xue Y et al.
Communications Biology, 2025
Targeting the untargetable: RB1-deficient tumours are vulnerable to Skp2 ubiquitin ligase inhibition.
Gupta P et al.
British Journal of Cancer, 2022
A cancer-associated CDKN1B mutation induces p27 phosphorylation on a novel residue: a new mechanism for tumor suppressor loss-of-function.
Bencivenga D et al.
Molecular Oncology, 2021
Skp2 is required for survival of aberrantly proliferating Rb1-deficient cells and for tumorigenesis in Rb1+/- mice.
Wang H et al.
Nature Genetics, 2010
Mutant B-RAF signaling and cyclin D1 regulate Cks1/S-phase kinase-associated protein 2-mediated degradation of p27Kip1 in human melanoma cells.
Bhatt KV et al.
Oncogene, 2007
Phosphorylation at serine 10, a major phosphorylation site of p27(Kip1), increases its protein stability.
Ishida N et al.
The Journal of Biological Chemistry, 2000
The nucleoside triphosphatase and helicase activities of vaccinia virus NPH-II are essential for virus replication.
Gross CH et al.
Journal of Virology, 1998
Synthetic lethality-based targets for discovery of new cancer therapeutics.
Weidle UH et al.
Cancer Genomics & Proteomics, 0
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