Varaico: Literature-Extracted Genetic Variants

Gene:CDKN1A
Variant:p.T145A
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CDKN1A

NM_000389.5:p.T145A

Associated Papers

Cytoplasmic p21 Mediates 5-Fluorouracil Resistance by Inhibiting Pro-Apoptotic Chk2.

Maiuthed A et al.

Cancers, 2018

PRMT6 increases cytoplasmic localization of p21CDKN1A in cancer cells through arginine methylation and makes more resistant to cytotoxic agents.

Nakakido M et al.

Oncotarget, 2015

EBNA3C augments Pim-1 mediated phosphorylation and degradation of p21 to promote B-cell proliferation.

Banerjee S et al.

Plos Pathogens, 2014

Bimodal regulation of p21(waf1) protein as function of DNA damage levels.

Buscemi G et al.

Cell Cycle (georgetown, Tex.), 2014

The p90 ribosomal S6 kinase (RSK) inhibitor BI-D1870 prevents gamma irradiation-induced apoptosis and mediates senescence via RSK- and p53-independent accumulation of p21WAF1/CIP1.

Neise D et al.

Cell Death & Disease, 2013

A functional role of the cyclin-dependent kinase inhibitor 1 (p21(WAF1/CIP1)) for neuronal preconditioning.

Mergenthaler P et al.

Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism, 2013

PCNA-dependent accumulation of CDKN1A into nuclear foci after ionizing irradiation.

Wiese C et al.

Dna Repair, 2012

BCCIP is required for the nuclear localization of the p21 protein.

Fan J et al.

Cell Cycle (georgetown, Tex.), 2009

p21WAF1/CIP1 regulates the p300 sumoylation motif CRD1 through a C-terminal domain independently of cyclin/CDK binding.

Garcia-Wilson E et al.

Cell Cycle (georgetown, Tex.), 2005

The association of cyclin A and cyclin kinase inhibitor p21 in response to gamma-irradiation requires the CDK2 binding region, but not the Cy motif.

Fukuchi K et al.

Biochimica Et Biophysica Acta, 2003

Phosphorylation of the cell cycle inhibitor p21Cip1/WAF1 by Pim-1 kinase.

Wang Z et al.

Biochimica Et Biophysica Acta, 2002

Cytoplasmic Localization of Cyclin Kinase Inhibitor p21 Delays the Progression of Apoptosis.

Arai D et al.

Cancer Genomics & Proteomics, 0

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."