Associated Papers
Structural Identification of Major Molecular Determinants for Phosphotyrosine Recognition in Tyrosine Kinases Reveals Tumour Promoting and Suppressive Functions.
Cheng N et al.
Biorxiv : the Preprint Server for Biology, 2025
EpoR Activation Stimulates Erythroid Precursor Proliferation by Inducing Phosphorylation of Tyrosine-88 of the CDK-Inhibitor p27Kip1.
Pegka F et al.
Cells, 2023
Inability to phosphorylate Y88 of p27Kip1 enforces reduced p27 protein levels and accelerates leukemia progression.
Jäkel H et al.
Leukemia, 2022
FLT3 and FLT3-ITD phosphorylate and inactivate the cyclin-dependent kinase inhibitor p27Kip1 in acute myeloid leukemia.
Peschel I et al.
Haematologica, 2017
Exposure of neuroblastoma cell lines to imatinib results in the upregulation of the CDK inhibitor p27(KIP1) as a consequence of c-Abl inhibition.
Lupino E et al.
Biochemical Pharmacology, 2014
Phosphorylation of p27Kip1 by JAK2 directly links cytokine receptor signaling to cell cycle control.
Jäkel H et al.
Oncogene, 2011
Cdk-inhibitory activity and stability of p27Kip1 are directly regulated by oncogenic tyrosine kinases.
Grimmler M et al.
Cell, 2007
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