Varaico: Literature-Extracted Genetic Variants

Gene:CDKN1B
Variant:p.S178A
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CDKN1B

NM_004064.5:p.S178A

Associated Papers

Oncogenic Ras blocks transforming growth factor-beta-induced cell-cycle arrest by degradation of p27 through a MEK/Erk/SKP2-dependent pathway.

Schepers H et al.

Experimental Hematology, 2005

The cyclin-dependent kinase inhibitor p27Kip1 is stabilized in G(0) by Mirk/dyrk1B kinase.

Deng X et al.

The Journal of Biological Chemistry, 2004

p27 cytoplasmic localization is regulated by phosphorylation on Ser10 and is not a prerequisite for its proteolysis.

Rodier G et al.

The Embo Journal, 2001

Ubiquitination of p27 is regulated by Cdk-dependent phosphorylation and trimeric complex formation.

Montagnoli A et al.

Genes & Development, 1999

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."