Associated Papers
Distinct outcomes from targeted perturbations of the multi-subunit SCFSkp2 E3 ubiquitin ligase in blocking Trp53/Rb1-null prostate tumorigenesis.
Xue Y et al.
Communications Biology, 2025
Regulation of p27 (Kip1) by Ubiquitin E3 Ligase RNF6.
Deshmukh D et al.
Pharmaceutics, 2022
A cancer-associated CDKN1B mutation induces p27 phosphorylation on a novel residue: a new mechanism for tumor suppressor loss-of-function.
Bencivenga D et al.
Molecular Oncology, 2021
Targeted Inhibition of the E3 Ligase SCFSkp2/Cks1 Has Antitumor Activity in RB1-Deficient Human and Mouse Small-Cell Lung Cancer.
Zhao H et al.
Cancer Research, 2020
Connexin Controls Cell-Cycle Exit and Cell Differentiation by Directly Promoting Cytosolic Localization and Degradation of E3 Ligase Skp2.
Shi Q et al.
Developmental Cell, 2015
Substituting threonine 187 with alanine in p27Kip1 prevents pituitary tumorigenesis by two-hit loss of Rb1 and enhances humoral immunity in old age.
Zhao H et al.
The Journal of Biological Chemistry, 2015
Racing to block tumorigenesis after pRb loss: an innocuous point mutation wins with synthetic lethality.
Bauzon F et al.
Cell Cycle (georgetown, Tex.), 2010
A functional link between Wnt signaling and SKP2-independent p27 turnover in mammary tumors.
Miranda-Carboni GA et al.
Genes & Development, 2008
Pim kinases promote cell cycle progression by phosphorylating and down-regulating p27Kip1 at the transcriptional and posttranscriptional levels.
Morishita D et al.
Cancer Research, 2008
Differential regulation of the cyclin-dependent kinase inhibitors p21(Cip1) and p27(Kip1) by phosphorylation directed by the cyclin encoded by Murine Herpesvirus 68.
Yarmishyn A et al.
Experimental Cell Research, 2008
A mechanism misregulating p27 in tumors discovered in a functional genomic screen.
Garrett-Engele CM et al.
Plos Genetics, 2007
Spy1 enhances phosphorylation and degradation of the cell cycle inhibitor p27.
McAndrew CW et al.
Cell Cycle (georgetown, Tex.), 2007
p27Kip1 localization depends on the tumor suppressor protein tuberin.
Rosner M et al.
Human Molecular Genetics, 2007
Substrate recognition and ubiquitination of SCFSkp2/Cks1 ubiquitin-protein isopeptide ligase.
Xu S et al.
The Journal of Biological Chemistry, 2007
Mutant B-RAF signaling and cyclin D1 regulate Cks1/S-phase kinase-associated protein 2-mediated degradation of p27Kip1 in human melanoma cells.
Bhatt KV et al.
Oncogene, 2007
Mutations of phosphorylation sites Ser10 and Thr187 of p27Kip1 abolish cytoplasmic redistribution but do not abrogate G0/1 phase arrest in the HepG2 cell line.
Guan X et al.
Biochemical and Biophysical Research Communications, 2006
A pathway in quiescent cells that controls p27Kip1 stability, subcellular localization, and tumor suppression.
Besson A et al.
Genes & Development, 2006
Ubiquitination of p27Kip1 requires physical interaction with cyclin E and probable phosphate recognition by SKP2.
Ungermannova D et al.
The Journal of Biological Chemistry, 2005
Oncogenic Ras blocks transforming growth factor-beta-induced cell-cycle arrest by degradation of p27 through a MEK/Erk/SKP2-dependent pathway.
Schepers H et al.
Experimental Hematology, 2005
Phosphorylation-independent stabilization of p27kip1 by the phosphoinositide 3-kinase pathway in glioblastoma cells.
Brandts CH et al.
The Journal of Biological Chemistry, 2005
Tuberin binds p27 and negatively regulates its interaction with the SCF component Skp2.
Rosner M et al.
The Journal of Biological Chemistry, 2004
The cyclin-dependent kinase inhibitor p27Kip1 is stabilized in G(0) by Mirk/dyrk1B kinase.
Deng X et al.
The Journal of Biological Chemistry, 2004
Cell cycle dysregulation in pituitary oncogenesis.
Muşat M et al.
Frontiers of Hormone Research, 2004
PAX3-FKHR transformation increases 26 S proteasome-dependent degradation of p27Kip1, a potential role for elevated Skp2 expression.
Zhang L et al.
The Journal of Biological Chemistry, 2003
Reduced expression of p27kip1 and increased hepatocyte proliferation in p53-deficient mice.
Yang C et al.
Molecular Carcinogenesis, 2003
PKB/Akt mediates cell-cycle progression by phosphorylation of p27(Kip1) at threonine 157 and modulation of its cellular localization.
Shin I et al.
Nature Medicine, 2002
Akt-dependent phosphorylation of p27Kip1 promotes binding to 14-3-3 and cytoplasmic localization.
Fujita N et al.
The Journal of Biological Chemistry, 2002
Transfection of p27(Kip1) threonine residue 187 mutant type gene, which is not influenced by ubiquitin-mediated degradation, induces cell cycle arrest in oral squamous cell carcinoma cells.
Kudo Y et al.
Oncology, 2002
p27 cytoplasmic localization is regulated by phosphorylation on Ser10 and is not a prerequisite for its proteolysis.
Rodier G et al.
The Embo Journal, 2001
A mouse knock-in model exposes sequential proteolytic pathways that regulate p27Kip1 in G1 and S phase.
Malek NP et al.
Nature, 2001
SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27.
Carrano AC et al.
Nature Cell Biology, 1999
Ubiquitination of p27 is regulated by Cdk-dependent phosphorylation and trimeric complex formation.
Montagnoli A et al.
Genes & Development, 1999
The cdk2 binding domain of p27Kip correlates with the inhibition of the kinase activity of cdk2/cyclin complexes.
Kwon TK et al.
Biochemical and Biophysical Research Communications, 1996