Associated Papers
Diversity of CFTR variants across ancestries characterized using 454,727 UK biobank whole exome sequences.
Ideozu JE et al.
Genome Medicine, 2024
Functionally additive fixed positive and negative charges in the CFTR channel pore control anion binding and conductance.
Linsdell P et al.
The Journal of Biological Chemistry, 2022
Two positively charged amino acid side-chains in the inner vestibule of the CFTR channel pore play analogous roles in controlling anion binding and anion conductance.
Linsdell P et al.
Cellular and Molecular Life Sciences : Cmls, 2021
On the relationship between anion binding and chloride conductance in the CFTR anion channel.
Linsdell P
Biochimica Et Biophysica Acta. Biomembranes, 2021
Structural mechanisms of CFTR function and dysfunction.
Hwang TC et al.
The Journal of General Physiology, 2018
Architecture and functional properties of the CFTR channel pore.
Linsdell P
Cellular and Molecular Life Sciences : Cmls, 2017
The pore architecture of the cystic fibrosis transmembrane conductance regulator channel revealed by co-mutation in pore-forming transmembrane regions.
Qian F et al.
Physiological Research, 2016
Anion conductance selectivity mechanism of the CFTR chloride channel.
Linsdell P
Biochimica Et Biophysica Acta, 2016
Interactions between permeant and blocking anions inside the CFTR chloride channel pore.
Linsdell P
Biochimica Et Biophysica Acta, 2015
Location of a permeant anion binding site in the cystic fibrosis transmembrane conductance regulator chloride channel pore.
Rubaiy HN et al.
The Journal of Physiological Sciences : Jps, 2015
State-dependent blocker interactions with the CFTR chloride channel: implications for gating the pore.
Linsdell P
Pflugers Archiv : European Journal of Physiology, 2014
Tuning of CFTR chloride channel function by location of positive charges within the pore.
El Hiani Y et al.
Biophysical Journal, 2012
Regulation of CFTR chloride channel macroscopic conductance by extracellular bicarbonate.
Li MS et al.
American Journal of Physiology. Cell Physiology, 2011
Mechanism of direct bicarbonate transport by the CFTR anion channel.
Tang L et al.
Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society, 2009
Molecular mechanism of arachidonic acid inhibition of the CFTR chloride channel.
Zhou JJ et al.
European Journal of Pharmacology, 2007
Identification of a second blocker binding site at the cytoplasmic mouth of the cystic fibrosis transmembrane conductance regulator chloride channel pore.
St Aubin CN et al.
Molecular Pharmacology, 2007
Direct and indirect effects of mutations at the outer mouth of the cystic fibrosis transmembrane conductance regulator chloride channel pore.
Zhou JJ et al.
The Journal of Membrane Biology, 2007
Location of a common inhibitor binding site in the cytoplasmic vestibule of the cystic fibrosis transmembrane conductance regulator chloride channel pore.
Linsdell P
The Journal of Biological Chemistry, 2005
Direct comparison of the functional roles played by different transmembrane regions in the cystic fibrosis transmembrane conductance regulator chloride channel pore.
Ge N et al.
The Journal of Biological Chemistry, 2004