Associated Papers
Target Identification with Live-Cell Photoaffinity Labeling and Mechanism of Action Elucidation of ARN23765, a Highly Potent CFTR Corrector.
Romeo E et al.
Journal of Medicinal Chemistry, 2025
Analysis of AlphaMissense data in different protein groups and structural context.
Tordai H et al.
Scientific Data, 2024
Folding correctors can restore CFTR posttranslational folding landscape by allosteric domain-domain coupling.
Soya N et al.
Nature Communications, 2023
Folding correctors can restore CFTR posttranslational folding landscape by allosteric domain-domain coupling.
Soya N et al.
Biorxiv : the Preprint Server for Biology, 2023
Rescue of Rare CFTR Trafficking Mutants Highlights a Structural Location-Dependent Pattern for Correction.
Zacarias S et al.
International Journal of Molecular Sciences, 2023
36834620 (PubMed )
Supplement: ijms-24-03211-s001.zip › ijms-2071953-supplementary.pdf
Co-Translational Folding of the First Transmembrane Domain of ABC-Transporter CFTR is Supported by Assembly with the First Cytosolic Domain.
Kleizen B et al.
Journal of Molecular Biology, 2021
Role of Protein Kinase A-Mediated Phosphorylation in CFTR Channel Activity Regulation.
Della Sala A et al.
Frontiers in Physiology, 2021
Correctors of the Major Cystic Fibrosis Mutant Interact through Membrane-Spanning Domains.
Laselva O et al.
Molecular Pharmacology, 2018
Mutation-specific downregulation of CFTR2 variants by gating potentiators.
Avramescu RG et al.
Human Molecular Genetics, 2017
Attenuation of Phosphorylation-dependent Activation of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) by Disease-causing Mutations at the Transmission Interface.
Chin S et al.
The Journal of Biological Chemistry, 2017
From CFTR biology toward combinatorial pharmacotherapy: expanded classification of cystic fibrosis mutations.
Veit G et al.
Molecular Biology of the Cell, 2016
Some gating potentiators, including VX-770, diminish ΔF508-CFTR functional expression.
Veit G et al.
Science Translational Medicine, 2014
Mechanism-based corrector combination restores ΔF508-CFTR folding and function.
Okiyoneda T et al.
Nature Chemical Biology, 2013
A combined analysis of the cystic fibrosis transmembrane conductance regulator: implications for structure and disease models.
Chen JM et al.
Molecular Biology and Evolution, 2001
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