Associated Papers
Novel gain-of-function mutants identify a critical region within CFTR membrane-spanning domain 2 controlling cAMP-dependent and ATP-independent channel activation.
Castanier S et al.
Cellular and Molecular Life Sciences : Cmls, 2024
Correction: Role of Hydrophobic Amino-Acid Side-Chains in the Narrow Selectivity Filter of the CFTR Chloride Channel Pore in Conductance and Selectivity.
Linsdell P
The Journal of Membrane Biology, 2024
Role of Hydrophobic Amino-Acid Side-Chains in the Narrow Selectivity Filter of the CFTR Chloride Channel Pore in Conductance and Selectivity.
Linsdell P
The Journal of Membrane Biology, 2023
Molecular mechanisms of cystic fibrosis - how mutations lead to misfunction and guide therapy.
Farinha CM et al.
Bioscience Reports, 2022
Monovalent: Divalent Anion Selectivity in the CFTR Channel Pore.
Linsdell P
Cell Biochemistry and Biophysics, 2021
Contribution of a leucine residue in the first transmembrane segment to the selectivity filter region in the CFTR chloride channel.
Negoda A et al.
Biochimica Et Biophysica Acta. Biomembranes, 2017
Architecture and functional properties of the CFTR channel pore.
Linsdell P
Cellular and Molecular Life Sciences : Cmls, 2017
Structural Changes Fundamental to Gating of the Cystic Fibrosis Transmembrane Conductance Regulator Anion Channel Pore.
Linsdell P
Advances in Experimental Medicine and Biology, 2017
Anion conductance selectivity mechanism of the CFTR chloride channel.
Linsdell P
Biochimica Et Biophysica Acta, 2016
Location of a permeant anion binding site in the cystic fibrosis transmembrane conductance regulator chloride channel pore.
Rubaiy HN et al.
The Journal of Physiological Sciences : Jps, 2015
Functional architecture of the CFTR chloride channel.
Linsdell P
Molecular Membrane Biology, 2014
Mutation-induced blocker permeability and multiion block of the CFTR chloride channel pore.
Gong X et al.
The Journal of General Physiology, 2003
Molecular determinants and role of an anion binding site in the external mouth of the CFTR chloride channel pore.
Gong X et al.
The Journal of Physiology, 2003
Mechanism of lonidamine inhibition of the CFTR chloride channel.
Gong X et al.
British Journal of Pharmacology, 2002
Molecular determinants of Au(CN)(2)(-) binding and permeability within the cystic fibrosis transmembrane conductance regulator Cl(-) channel pore.
Gong X et al.
The Journal of Physiology, 2002
Asymmetric structure of the cystic fibrosis transmembrane conductance regulator chloride channel pore suggested by mutagenesis of the twelfth transmembrane region.
Gupta J et al.
Biochemistry, 2001
Relationship between anion binding and anion permeability revealed by mutagenesis within the cystic fibrosis transmembrane conductance regulator chloride channel pore.
Linsdell P
The Journal of Physiology, 2001
Molecular determinants of anion selectivity in the cystic fibrosis transmembrane conductance regulator chloride channel pore.
Linsdell P et al.
Biophysical Journal, 2000