Associated Papers
Structural basis for CFTR inhibition by CFTRinh-172.
Young PG et al.
Proceedings of the National Academy of Sciences of the United States of America, 2024
CFTR function, pathology and pharmacology at single-molecule resolution.
Levring J et al.
Nature, 2023
Contribution of a leucine residue in the first transmembrane segment to the selectivity filter region in the CFTR chloride channel.
Negoda A et al.
Biochimica Et Biophysica Acta. Biomembranes, 2017
Functional differences in pore properties between wild-type and cysteine-less forms of the CFTR chloride channel.
Holstead RG et al.
The Journal of Membrane Biology, 2011
Cystic fibrosis transmembrane conductance regulator: using differential reactivity toward channel-permeant and channel-impermeant thiol-reactive probes to test a molecular model for the pore.
Alexander C et al.
Biochemistry, 2009
In vivo phosphorylation of CFTR promotes formation of a nucleotide-binding domain heterodimer.
Mense M et al.
The Embo Journal, 2006
CFTR: Ligand exchange between a permeant anion ([Au(CN)2]-) and an engineered cysteine (T338C) blocks the pore.
Serrano JR et al.
Biophysical Journal, 2006
The DeltaF508 mutation disrupts packing of the transmembrane segments of the cystic fibrosis transmembrane conductance regulator.
Chen EY et al.
The Journal of Biological Chemistry, 2004
Intracellular cysteines of the cystic fibrosis transmembrane conductance regulator (CFTR) modulate channel gating.
Ketchum CJ et al.
Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology, 2002
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