Associated Papers
Structural mechanisms of CFTR function and dysfunction.
Hwang TC et al.
The Journal of General Physiology, 2018
29581173 (PubMed )
Supplement: JGP_201711946_TableS1.pdf
Transmembrane helical interactions in the CFTR channel pore.
Das J et al.
Plos Computational Biology, 2017
Cytoplasmic pathway followed by chloride ions to enter the CFTR channel pore.
El Hiani Y et al.
Cellular and Molecular Life Sciences : Cmls, 2016
The cystic fibrosis V232D mutation inhibits CFTR maturation by disrupting a hydrophobic pocket rather than formation of aberrant interhelical hydrogen bonds.
Loo TW et al.
Biochemical Pharmacology, 2014
Functional architecture of the CFTR chloride channel.
Linsdell P
Molecular Membrane Biology, 2014
The V510D suppressor mutation stabilizes DeltaF508-CFTR at the cell surface.
Loo TW et al.
Biochemistry, 2010
Atomic model of human cystic fibrosis transmembrane conductance regulator: membrane-spanning domains and coupling interfaces.
Mornon JP et al.
Cellular and Molecular Life Sciences : Cmls, 2008
Correctors promote folding of the CFTR in the endoplasmic reticulum.
Loo TW et al.
The Biochemical Journal, 2008
The chemical chaperone CFcor-325 repairs folding defects in the transmembrane domains of CFTR-processing mutants.
Loo TW et al.
The Biochemical Journal, 2006
The DeltaF508 mutation disrupts packing of the transmembrane segments of the cystic fibrosis transmembrane conductance regulator.
Chen EY et al.
The Journal of Biological Chemistry, 2004
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