Associated Papers
Correctors of ΔF508 CFTR restore global conformational maturation without thermally stabilizing the mutant protein.
He L et al.
Faseb Journal : Official Publication of the Federation of American Societies for Experimental Biology, 2013
Allosteric modulation balances thermodynamic stability and restores function of ΔF508 CFTR.
Aleksandrov AA et al.
Journal of Molecular Biology, 2012
Regulatory insertion removal restores maturation, stability and function of DeltaF508 CFTR.
Aleksandrov AA et al.
Journal of Molecular Biology, 2010
Restoration of domain folding and interdomain assembly by second-site suppressors of the DeltaF508 mutation in CFTR.
He L et al.
Faseb Journal : Official Publication of the Federation of American Societies for Experimental Biology, 2010
Phenylalanine-508 mediates a cytoplasmic-membrane domain contact in the CFTR 3D structure crucial to assembly and channel function.
Serohijos AW et al.
Proceedings of the National Academy of Sciences of the United States of America, 2008
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