Associated Papers
A cluster of inhibitory residues in the regulatory domain prevents activation of the cystic fibrosis transmembrane conductance regulator.
Wu M et al.
The Journal of Biological Chemistry, 2025
Extracellular phosphate enhances the function of F508del-CFTR rescued by CFTR correctors.
Saint-Criq V et al.
Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society, 2021
Protein kinase A phosphorylation potentiates cystic fibrosis transmembrane conductance regulator gating by relieving autoinhibition on the stimulatory C terminus of the regulatory domain.
Chen JH
The Journal of Biological Chemistry, 2020
Molecular Basis for Fe(III)-Independent Curcumin Potentiation of Cystic Fibrosis Transmembrane Conductance Regulator Activity.
Wang G
Biochemistry, 2015
Interplay between inhibitory ferric and stimulatory curcumin regulates phosphorylation-dependent human cystic fibrosis transmembrane conductance regulator and ΔF508 activity.
Wang G
Biochemistry, 2015
Role of tyrosine phosphorylation in the muscarinic activation of the cystic fibrosis transmembrane conductance regulator (CFTR).
Billet A et al.
The Journal of Biological Chemistry, 2013
Regulation of activation and processing of the cystic fibrosis transmembrane conductance regulator (CFTR) by a complex electrostatic interaction between the regulatory domain and cytoplasmic loop 3.
Wang G et al.
The Journal of Biological Chemistry, 2012
The inhibition mechanism of non-phosphorylated Ser768 in the regulatory domain of cystic fibrosis transmembrane conductance regulator.
Wang G
The Journal of Biological Chemistry, 2011
State-dependent regulation of cystic fibrosis transmembrane conductance regulator (CFTR) gating by a high affinity Fe3+ bridge between the regulatory domain and cytoplasmic loop 3.
Wang G
The Journal of Biological Chemistry, 2010
ATP-independent CFTR channel gating and allosteric modulation by phosphorylation.
Wang W et al.
Proceedings of the National Academy of Sciences of the United States of America, 2010
Direct sensing of intracellular pH by the cystic fibrosis transmembrane conductance regulator (CFTR) Cl- channel.
Chen JH et al.
The Journal of Biological Chemistry, 2009
AMP-activated protein kinase phosphorylation of the R domain inhibits PKA stimulation of CFTR.
King JD et al.
American Journal of Physiology. Cell Physiology, 2009
Potentiation of cystic fibrosis transmembrane conductance regulator (CFTR) Cl- currents by the chemical solvent tetrahydrofuran.
Hughes LK et al.
Molecular Membrane Biology, 2008
Cystic fibrosis transmembrane conductance regulator: a chloride channel gated by ATP binding and hydrolysis.
Bompadre SG et al.
Sheng Li Xue Bao : [acta Physiologica Sinica], 2007
CFTR regulatory region interacts with NBD1 predominantly via multiple transient helices.
Baker JM et al.
Nature Structural & Molecular Biology, 2007
Curcumin opens cystic fibrosis transmembrane conductance regulator channels by a novel mechanism that requires neither ATP binding nor dimerization of the nucleotide-binding domains.
Wang W et al.
The Journal of Biological Chemistry, 2007
Activating cystic fibrosis transmembrane conductance regulator channels with pore blocker analogs.
Wang W et al.
The Journal of Biological Chemistry, 2005
Reversible silencing of CFTR chloride channels by glutathionylation.
Wang W et al.
The Journal of General Physiology, 2005
Functional roles of nonconserved structural segments in CFTR's NH2-terminal nucleotide binding domain.
Csanády L et al.
The Journal of General Physiology, 2005
Molecular dissection of the butyrate action revealed the involvement of mitogen-activated protein kinase in cystic fibrosis transmembrane conductance regulator biogenesis.
Sugita M et al.
Molecular Pharmacology, 2004
Capsaicin potentiates wild-type and mutant cystic fibrosis transmembrane conductance regulator chloride-channel currents.
Ai T et al.
Molecular Pharmacology, 2004
Protein kinase A regulates ATP hydrolysis and dimerization by a CFTR (cystic fibrosis transmembrane conductance regulator) domain.
Howell LD et al.
The Biochemical Journal, 2004
Cystic fibrosis transmembrane conductance regulator Cl- channels with R domain deletions and translocations show phosphorylation-dependent and -independent activity.
Baldursson O et al.
The Journal of Biological Chemistry, 2001
Contribution of R domain phosphoserines to the function of CFTR studied in Fischer rat thyroid epithelia.
Baldursson O et al.
American Journal of Physiology. Lung Cellular and Molecular Physiology, 2000
Severed channels probe regulation of gating of cystic fibrosis transmembrane conductance regulator by its cytoplasmic domains.
Csanády L et al.
The Journal of General Physiology, 2000
CFTR chloride channel regulation by an interdomain interaction.
Naren AP et al.
Science (new York, N.y.), 1999
Structure and function of the CFTR chloride channel.
Sheppard DN et al.
Physiological Reviews, 1999
Control of CFTR channel gating by phosphorylation and nucleotide hydrolysis.
Gadsby DC et al.
Physiological Reviews, 1999
Regulation of murine cystic fibrosis transmembrane conductance regulator Cl- channels expressed in Chinese hamster ovary cells.
Lansdell KA et al.
The Journal of Physiology, 1998
Fluoride stimulates cystic fibrosis transmembrane conductance regulator Cl- channel activity.
Berger HA et al.
The American Journal of Physiology, 1998
CFTR Cl- channel and CFTR-associated ATP channel: distinct pores regulated by common gates.
Sugita M et al.
The Embo Journal, 1998
Stimulation of CFTR activity by its phosphorylated R domain.
Winter MC et al.
Nature, 1997
CFTR activation: additive effects of stimulatory and inhibitory phosphorylation sites in the R domain.
Wilkinson DJ et al.
The American Journal of Physiology, 1997
Phosphorylation-dependent block of cystic fibrosis transmembrane conductance regulator chloride channel by exogenous R domain protein.
Ma J et al.
The Journal of Biological Chemistry, 1996
Pyrophosphate stimulates wild-type and mutant cystic fibrosis transmembrane conductance regulator Cl- channels.
Carson MR et al.
The Journal of Biological Chemistry, 1995
The two nucleotide-binding domains of cystic fibrosis transmembrane conductance regulator (CFTR) have distinct functions in controlling channel activity.
Carson MR et al.
The Journal of Biological Chemistry, 1995
Regulation of the cystic fibrosis transmembrane conductance regulator Cl- channel by negative charge in the R domain.
Berger HA et al.
The Japanese Journal of Physiology, 1994
Regulation of the cystic fibrosis transmembrane conductance regulator Cl- channel by negative charge in the R domain.
Rich DP et al.
The Journal of Biological Chemistry, 1993
Protein kinase A (PKA) still activates CFTR chloride channel after mutagenesis of all 10 PKA consensus phosphorylation sites.
Chang XB et al.
The Journal of Biological Chemistry, 1993
Phosphorylation of the R domain by cAMP-dependent protein kinase regulates the CFTR chloride channel.
Cheng SH et al.
Cell, 1991