Associated Papers
A cluster of inhibitory residues in the regulatory domain prevents activation of the cystic fibrosis transmembrane conductance regulator.
Wu M et al.
The Journal of Biological Chemistry, 2025
Blue flash sheds light on the roles of individual phosphoserines in CFTR channel activation.
Csanády L
The Journal of General Physiology, 2023
Real-time observation of functional specialization among phosphorylation sites in CFTR.
Infield DT et al.
The Journal of General Physiology, 2023
A PI3Kγ mimetic peptide triggers CFTR gating, bronchodilation, and reduced inflammation in obstructive airway diseases.
Ghigo A et al.
Science Translational Medicine, 2022
Protein kinase A phosphorylation potentiates cystic fibrosis transmembrane conductance regulator gating by relieving autoinhibition on the stimulatory C terminus of the regulatory domain.
Chen JH
The Journal of Biological Chemistry, 2020
STRUCTURE, GATING, AND REGULATION OF THE CFTR ANION CHANNEL.
Csanády L et al.
Physiological Reviews, 2019
Trafficking and function of the cystic fibrosis transmembrane conductance regulator: a complex network of posttranslational modifications.
McClure ML et al.
American Journal of Physiology. Lung Cellular and Molecular Physiology, 2016
Molecular Basis for Fe(III)-Independent Curcumin Potentiation of Cystic Fibrosis Transmembrane Conductance Regulator Activity.
Wang G
Biochemistry, 2015
Sphingosine-1-Phosphate Is a Novel Regulator of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Activity.
Malik FA et al.
Plos One, 2015
LMTK2-mediated phosphorylation regulates CFTR endocytosis in human airway epithelial cells.
Luz S et al.
The Journal of Biological Chemistry, 2014
Role of tyrosine phosphorylation in the muscarinic activation of the cystic fibrosis transmembrane conductance regulator (CFTR).
Billet A et al.
The Journal of Biological Chemistry, 2013
Structural models of CFTR-AMPK and CFTR-PKA interactions: R-domain flexibility is a key factor in CFTR regulation.
Siwiak M et al.
Journal of Molecular Modeling, 2012
The inhibition mechanism of non-phosphorylated Ser768 in the regulatory domain of cystic fibrosis transmembrane conductance regulator.
Wang G
The Journal of Biological Chemistry, 2011
Effect of Annexin A5 on CFTR: regulated traffic or scaffolding?
Faria D et al.
Molecular Membrane Biology, 2011
State-dependent regulation of cystic fibrosis transmembrane conductance regulator (CFTR) gating by a high affinity Fe3+ bridge between the regulatory domain and cytoplasmic loop 3.
Wang G
The Journal of Biological Chemistry, 2010
Role of individual R domain phosphorylation sites in CFTR regulation by protein kinase A.
Hegedus T et al.
Biochimica Et Biophysica Acta, 2009
Mechanistic insight into control of CFTR by AMPK.
Kongsuphol P et al.
The Journal of Biological Chemistry, 2009
Cystic fibrosis transmembrane conductance regulator: a chloride channel gated by ATP binding and hydrolysis.
Bompadre SG et al.
Sheng Li Xue Bao : [acta Physiologica Sinica], 2007
Preferential phosphorylation of R-domain Serine 768 dampens activation of CFTR channels by PKA.
Csanády L et al.
The Journal of General Physiology, 2005
Capsaicin potentiates wild-type and mutant cystic fibrosis transmembrane conductance regulator chloride-channel currents.
Ai T et al.
Molecular Pharmacology, 2004
Protein kinase A regulates ATP hydrolysis and dimerization by a CFTR (cystic fibrosis transmembrane conductance regulator) domain.
Howell LD et al.
The Biochemical Journal, 2004
Regulation of the cystic fibrosis transmembrane conductance regulator Cl- channel by its R domain.
Ostedgaard LS et al.
The Journal of Biological Chemistry, 2001
Contribution of R domain phosphoserines to the function of CFTR studied in Fischer rat thyroid epithelia.
Baldursson O et al.
American Journal of Physiology. Lung Cellular and Molecular Physiology, 2000
Stimulatory and Inhibitory Functions of the R Domain on CFTR Chloride Channel.
Ma J
News in Physiological Sciences : an International Journal of Physiology Produced Jointly by the International Union of Physiological Sciences and the American Physiological Society, 2000
Structure and function of the CFTR chloride channel.
Sheppard DN et al.
Physiological Reviews, 1999
Stimulation of CFTR activity by its phosphorylated R domain.
Winter MC et al.
Nature, 1997
CFTR activation: additive effects of stimulatory and inhibitory phosphorylation sites in the R domain.
Wilkinson DJ et al.
The American Journal of Physiology, 1997
cAMP-dependent protein kinase-mediated phosphorylation of cystic fibrosis transmembrane conductance regulator residue Ser-753 and its role in channel activation.
Seibert FS et al.
The Journal of Biological Chemistry, 1995
Regulation of the cystic fibrosis transmembrane conductance regulator Cl- channel by negative charge in the R domain.
Berger HA et al.
The Japanese Journal of Physiology, 1994
Regulation of the cystic fibrosis transmembrane conductance regulator Cl- channel by negative charge in the R domain.
Rich DP et al.
The Journal of Biological Chemistry, 1993
Protein kinase A (PKA) still activates CFTR chloride channel after mutagenesis of all 10 PKA consensus phosphorylation sites.
Chang XB et al.
The Journal of Biological Chemistry, 1993
Phosphorylation of the R domain by cAMP-dependent protein kinase regulates the CFTR chloride channel.
Cheng SH et al.
Cell, 1991