Associated Papers
Structural basis for CFTR inhibition by CFTRinh-172.
Young PG et al.
Proceedings of the National Academy of Sciences of the United States of America, 2024
CFTR function, pathology and pharmacology at single-molecule resolution.
Levring J et al.
Nature, 2023
Molecular Basis for Fe(III)-Independent Curcumin Potentiation of Cystic Fibrosis Transmembrane Conductance Regulator Activity.
Wang G
Biochemistry, 2015
Cysteine accessibility probes timing and extent of NBD separation along the dimer interface in gating CFTR channels.
Chaves LA et al.
The Journal of General Physiology, 2015
Cystic fibrosis transmembrane conductance regulator: using differential reactivity toward channel-permeant and channel-impermeant thiol-reactive probes to test a molecular model for the pore.
Alexander C et al.
Biochemistry, 2009
In vivo phosphorylation of CFTR promotes formation of a nucleotide-binding domain heterodimer.
Mense M et al.
The Embo Journal, 2006
CFTR: Ligand exchange between a permeant anion ([Au(CN)2]-) and an engineered cysteine (T338C) blocks the pore.
Serrano JR et al.
Biophysical Journal, 2006
The DeltaF508 mutation disrupts packing of the transmembrane segments of the cystic fibrosis transmembrane conductance regulator.
Chen EY et al.
The Journal of Biological Chemistry, 2004
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