Associated Papers
Estimating the true stability of the prehydrolytic outward-facing state in an ABC protein.
Simon MA et al.
Elife, 2023
Potentiation of the cystic fibrosis transmembrane conductance regulator by VX-770 involves stabilization of the pre-hydrolytic, O1 state.
Langron E et al.
British Journal of Pharmacology, 2018
Asymmetry of movements in CFTR's two ATP sites during pore opening serves their distinct functions.
Sorum B et al.
Elife, 2017
Obligate coupling of CFTR pore opening to tight nucleotide-binding domain dimerization.
Mihályi C et al.
Elife, 2016
New structural insights into the gating movements of CFTR.
Puljung MC
The Journal of General Physiology, 2015
Cysteine accessibility probes timing and extent of NBD separation along the dimer interface in gating CFTR channels.
Chaves LA et al.
The Journal of General Physiology, 2015
Nonintegral stoichiometry in CFTR gating revealed by a pore-lining mutation.
Jih KY et al.
The Journal of General Physiology, 2012
Mutant cycles at CFTR's non-canonical ATP-binding site support little interface separation during gating.
Szollosi A et al.
The Journal of General Physiology, 2011
Involvement of F1296 and N1303 of CFTR in induced-fit conformational change in response to ATP binding at NBD2.
Szollosi A et al.
The Journal of General Physiology, 2010
Strict coupling between CFTR's catalytic cycle and gating of its Cl- ion pore revealed by distributions of open channel burst durations.
Csanády L et al.
Proceedings of the National Academy of Sciences of the United States of America, 2010
Review. ATP hydrolysis-driven gating in cystic fibrosis transmembrane conductance regulator.
Muallem D et al.
Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences, 2009
Thermodynamics of CFTR channel gating: a spreading conformational change initiates an irreversible gating cycle.
Csanády L et al.
The Journal of General Physiology, 2006
CFTR channel opening by ATP-driven tight dimerization of its nucleotide-binding domains.
Vergani P et al.
Nature, 2005
CFTR: the nucleotide binding folds regulate the accessibility and stability of the activated state.
Wilkinson DJ et al.
The Journal of General Physiology, 1996