Associated Papers
Structural basis for CFTR inhibition by CFTRinh-172.
Young PG et al.
Proceedings of the National Academy of Sciences of the United States of America, 2024
Estimating the true stability of the prehydrolytic outward-facing state in an ABC protein.
Simon MA et al.
Elife, 2023
Molecular pathology of the R117H cystic fibrosis mutation is explained by loss of a hydrogen bond.
Simon MA et al.
Elife, 2021
Functional stability of CFTR depends on tight binding of ATP at its degenerate ATP-binding site.
Yeh HI et al.
The Journal of Physiology, 2021
STRUCTURE, GATING, AND REGULATION OF THE CFTR ANION CHANNEL.
Csanády L et al.
Physiological Reviews, 2019
Potentiation of the cystic fibrosis transmembrane conductance regulator Cl- channel by ivacaftor is temperature independent.
Wang Y et al.
American Journal of Physiology. Lung Cellular and Molecular Physiology, 2018
Potentiation of the cystic fibrosis transmembrane conductance regulator by VX-770 involves stabilization of the pre-hydrolytic, O1 state.
Langron E et al.
British Journal of Pharmacology, 2018
Structural mechanisms of CFTR function and dysfunction.
Hwang TC et al.
The Journal of General Physiology, 2018
A common mechanism for CFTR potentiators.
Yeh HI et al.
The Journal of General Physiology, 2017
Asymmetry of movements in CFTR's two ATP sites during pore opening serves their distinct functions.
Sorum B et al.
Elife, 2017
Timing of CFTR pore opening and structure of its transition state.
Sorum B et al.
Cell, 2015
Modulation of CFTR gating by permeant ions.
Yeh HI et al.
The Journal of General Physiology, 2015
ATP and AMP mutually influence their interaction with the ATP-binding cassette (ABC) adenylate kinase cystic fibrosis transmembrane conductance regulator (CFTR) at separate binding sites.
Randak CO et al.
The Journal of Biological Chemistry, 2013
Demonstration of phosphoryl group transfer indicates that the ATP-binding cassette (ABC) transporter cystic fibrosis transmembrane conductance regulator (CFTR) exhibits adenylate kinase activity.
Randak CO et al.
The Journal of Biological Chemistry, 2012
State-dependent regulation of cystic fibrosis transmembrane conductance regulator (CFTR) gating by a high affinity Fe3+ bridge between the regulatory domain and cytoplasmic loop 3.
Wang G
The Journal of Biological Chemistry, 2010
On the mechanism of CFTR inhibition by a thiazolidinone derivative.
Kopeikin Z et al.
The Journal of General Physiology, 2010
Involvement of F1296 and N1303 of CFTR in induced-fit conformational change in response to ATP binding at NBD2.
Szollosi A et al.
The Journal of General Physiology, 2010
Strict coupling between CFTR's catalytic cycle and gating of its Cl- ion pore revealed by distributions of open channel burst durations.
Csanády L et al.
Proceedings of the National Academy of Sciences of the United States of America, 2010
Direct sensing of intracellular pH by the cystic fibrosis transmembrane conductance regulator (CFTR) Cl- channel.
Chen JH et al.
The Journal of Biological Chemistry, 2009
Review. ATP hydrolysis-driven gating in cystic fibrosis transmembrane conductance regulator.
Muallem D et al.
Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences, 2009
A mutation in CFTR modifies the effects of the adenylate kinase inhibitor Ap5A on channel gating.
Dong Q et al.
Biophysical Journal, 2008
Insight in eukaryotic ABC transporter function by mutation analysis.
Frelet A et al.
Febs Letters, 2006
CFTR gating I: Characterization of the ATP-dependent gating of a phosphorylation-independent CFTR channel (DeltaR-CFTR).
Bompadre SG et al.
The Journal of General Physiology, 2005
CFTR gating II: Effects of nucleotide binding on the stability of open states.
Bompadre SG et al.
The Journal of General Physiology, 2005
A heteromeric complex of the two nucleotide binding domains of cystic fibrosis transmembrane conductance regulator (CFTR) mediates ATPase activity.
Kidd JF et al.
The Journal of Biological Chemistry, 2004
An intrinsic adenylate kinase activity regulates gating of the ABC transporter CFTR.
Randak C et al.
Cell, 2003
On the mechanism of MgATP-dependent gating of CFTR Cl- channels.
Vergani P et al.
The Journal of General Physiology, 2003
Down-regulation of volume-sensitive Cl- channels by CFTR is mediated by the second nucleotide-binding domain.
Ando-Akatsuka Y et al.
Pflugers Archiv : European Journal of Physiology, 2002
ATP hydrolysis-coupled gating of CFTR chloride channels: structure and function.
Zou X et al.
Biochemistry, 2001
Regulation of Cl-/ HCO3- exchange by cystic fibrosis transmembrane conductance regulator expressed in NIH 3T3 and HEK 293 cells.
Lee MG et al.
The Journal of Biological Chemistry, 1999
CFTR: the nucleotide binding folds regulate the accessibility and stability of the activated state.
Wilkinson DJ et al.
The Journal of General Physiology, 1996
Epitope tagging permits cell surface detection of functional CFTR.
Howard M et al.
The American Journal of Physiology, 1995
Conformational states of CFTR associated with channel gating: the role ATP binding and hydrolysis.
Gunderson KL et al.
Cell, 1995
Regulation by ATP and ADP of CFTR chloride channels that contain mutant nucleotide-binding domains.
Anderson MP et al.
Science (new York, N.y.), 1992
Maturation and function of cystic fibrosis transmembrane conductance regulator variants bearing mutations in putative nucleotide-binding domains 1 and 2.
Gregory RJ et al.
Molecular and Cellular Biology, 1991