Associated Papers
Reconstitution of CFTR ubiquitination identifies lysine-420 as a regulator of cell surface residence and current.
Goeckeler-Fried JL et al.
Biochemistry and Biophysics Reports, 2026
Two distinct mechanisms for GlyH-101 block of the CFTR chloride channel.
Chang YC et al.
The Journal of Physiology, 2026
Native CFTR codon bias controls translation rate to balance off-pathway aggregation and channel function by conformational imprinting.
Yoon JS et al.
Scientific Reports, 2025
Molecular and pharmacological evaluation of rare, cystic fibrosis-causing missense mutations of the CFTR channel.
Závoti O et al.
The Journal of Physiology, 2025
Thermodynamic Coupling between Folding Correctors and the First of Dimerized Nucleotide Binding Domains in CFTR.
Wang G
Acs Bio & Med Chem Au, 2025
Structure of CFTR bound to (R)-BPO-27 unveils a pore-blockage mechanism.
Young PG et al.
Nature Communications, 2025
Thermodynamic coupling between folding correctors and the first of dimerized nucleotide binding domains in CFTR.
Wang G
Research Square, 2025
Trikafta rescues F508del-CFTR by tightening specific phosphorylation-dependent interdomain interactions.
Wang G
Biorxiv : the Preprint Server for Biology, 2025
Discovery and Development of CFTR Modulators for the Treatment of Cystic Fibrosis.
Wang X et al.
Journal of Medicinal Chemistry, 2025
Unraveling the Mechanism of Action, Binding Sites, and Therapeutic Advances of CFTR Modulators: A Narrative Review.
Baroni D
Current Issues in Molecular Biology, 2025
The structures of protein kinase A in complex with CFTR: Mechanisms of phosphorylation and noncatalytic activation.
Fiedorczuk K et al.
Proceedings of the National Academy of Sciences of the United States of America, 2024
Allosteric inhibition of CFTR gating by CFTRinh-172 binding in the pore.
Gao X et al.
Nature Communications, 2024
The Folding Pathway of ABC Transporter CFTR: Effective and Robust.
van der Sluijs P et al.
Journal of Molecular Biology, 2024
Structure-based discovery of CFTR potentiators and inhibitors.
Liu F et al.
Cell, 2024
Correction: Role of Hydrophobic Amino-Acid Side-Chains in the Narrow Selectivity Filter of the CFTR Chloride Channel Pore in Conductance and Selectivity.
Linsdell P
The Journal of Membrane Biology, 2024
Functional Consequences of CFTR Interactions in Cystic Fibrosis.
Ramananda Y et al.
International Journal of Molecular Sciences, 2024
Structure-based discovery of CFTR potentiators and inhibitors.
Liu F et al.
Biorxiv : the Preprint Server for Biology, 2024
Structural basis for CFTR inhibition by CFTRinh-172.
Young PG et al.
Proceedings of the National Academy of Sciences of the United States of America, 2024
Structural identification of a selectivity filter in CFTR.
Levring J et al.
Proceedings of the National Academy of Sciences of the United States of America, 2024
Synthesis and Evaluation of Ivacaftor Derivatives with Reduced Lipophilicity.
Iazzi M et al.
Acs Omega, 2023
Role of Hydrophobic Amino-Acid Side-Chains in the Narrow Selectivity Filter of the CFTR Chloride Channel Pore in Conductance and Selectivity.
Linsdell P
The Journal of Membrane Biology, 2023
Folding correctors can restore CFTR posttranslational folding landscape by allosteric domain-domain coupling.
Soya N et al.
Nature Communications, 2023
Folding correctors can restore CFTR posttranslational folding landscape by allosteric domain-domain coupling.
Soya N et al.
Biorxiv : the Preprint Server for Biology, 2023
Estimating the true stability of the prehydrolytic outward-facing state in an ABC protein.
Simon MA et al.
Elife, 2023
Computational Exploration of Potential CFTR Binding Sites for Type I Corrector Drugs.
Lester A et al.
Biochemistry, 2023
Optimization of CFTR gating through the evolution of its extracellular loops.
Simon MA et al.
The Journal of General Physiology, 2023
CFTR function, pathology and pharmacology at single-molecule resolution.
Levring J et al.
Nature, 2023
Structure basis of CFTR folding, function and pharmacology.
Hwang TC et al.
Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society, 2023
Molecular dynamics study of Cl- permeation through cystic fibrosis transmembrane conductance regulator (CFTR).
Zeng ZW et al.
Cellular and Molecular Life Sciences : Cmls, 2023
Mechanistic insights on KATP channel regulation from cryo-EM structures.
Driggers CM et al.
The Journal of General Physiology, 2023
Molecular structures reveal synergistic rescue of Δ508 CFTR by Trikafta modulators.
Fiedorczuk K et al.
Science (new York, N.y.), 2022
Conformational Variability in Ground-State CFTR Lipoprotein Particle Cryo-EM Ensembles.
Aleksandrov LA et al.
International Journal of Molecular Sciences, 2022
Molecular Dynamics and Theratyping in Airway and Gut Organoids Reveal R352Q-CFTR Conductance Defect.
Wong SL et al.
American Journal of Respiratory Cell and Molecular Biology, 2022
Structural Comparative Modeling of Multi-Domain F508del CFTR.
McDonald EF et al.
Biomolecules, 2022
Functionally additive fixed positive and negative charges in the CFTR channel pore control anion binding and conductance.
Linsdell P et al.
The Journal of Biological Chemistry, 2022