Varaico: Literature-Extracted Genetic Variants

Gene:CGAS
Variant:p.K394E
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CGAS

NM_138441.3:p.K394E

Associated Papers

cGAS restricts PARP1-mediated microhomology-mediated end joining by suppressing poly-ADP-ribosylation.

Yang H et al.

Cell Death and Differentiation, 2025

cGAS and DDX41-STING mediated intrinsic immunity spreads intercellularly to promote neuroinflammation in SOD1 ALS model.

Tan HY et al.

Iscience, 2022

Identification of SNPs Associated with Stress Response Traits within High Stress and Low Stress Lines of Japanese Quail.

Shumaker S et al.

Genes, 2021

33809122 (PubMed )
Supplement: genes-12-00405-s001.zip › Supplemental_Material_1_HS_Line_SNPs.xlsx › Sheet1

The molecular basis of tight nuclear tethering and inactivation of cGAS.

Zhao B et al.

Nature, 2020

cGAS suppresses genomic instability as a decelerator of replication forks.

Chen H et al.

Science Advances, 2020

Chromatin-bound cGAS is an inhibitor of DNA repair and hence accelerates genome destabilization and cell death.

Jiang H et al.

The Embo Journal, 2019

Structure of human cGAS reveals a conserved family of second-messenger enzymes in innate immunity.

Kranzusch PJ et al.

Cell Reports, 2013

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."