Associated Papers
Nuclear rupture in confined cell migration triggers nuclear actin polymerization to limit chromatin leakage.
Kamaras C et al.
The Embo Journal, 2025
Microtubule forces drive nuclear damage in LMNA cardiomyopathy.
Amiad Pavlov D et al.
Nature Cardiovascular Research, 2025
N-terminal tags impair the ability of lamin A to provide structural support to the nucleus.
Odell J et al.
Journal of Cell Science, 2024
N-terminal tags impair the ability of Lamin A to provide structural support to the nucleus.
Odell J et al.
Biorxiv : the Preprint Server for Biology, 2024
Pervasive nuclear envelope ruptures precede ECM signaling and disease onset without activating cGAS-STING in Lamin-cardiomyopathy mice.
En A et al.
Cell Reports, 2024
Pervasive nuclear envelope ruptures precede ECM signaling and disease onset without activating cGAS-STING in Lamin-cardiomyopathy mice.
En A et al.
Biorxiv : the Preprint Server for Biology, 2024
Nuclear cGAS restricts L1 retrotransposition by promoting TRIM41-mediated ORF2p ubiquitination and degradation.
Zhen Z et al.
Nature Communications, 2023
DNA damage induces nuclear envelope rupture through ATR-mediated phosphorylation of lamin A/C.
Kovacs MT et al.
Molecular Cell, 2023
Multi-functional regulation of cGAS by the nuclear localization signal2 (NLS2) motif: Nuclear localization, enzyme activity and protein degradation.
Kim EY et al.
Biochemical and Biophysical Research Communications, 2023
Lem2 is essential for cardiac development by maintaining nuclear integrity.
Ross JA et al.
Cardiovascular Research, 2023
Cytosolic DNA sensing by cGAS/STING promotes TRPV2-mediated Ca2+ release to protect stressed replication forks.
Li S et al.
Molecular Cell, 2023
Interruption of post-Golgi STING trafficking activates tonic interferon signaling.
Tu X et al.
Nature Communications, 2022
cGAS and DDX41-STING mediated intrinsic immunity spreads intercellularly to promote neuroinflammation in SOD1 ALS model.
Tan HY et al.
Iscience, 2022
CGAS is a micronucleophagy receptor for the clearance of micronuclei.
Zhao M et al.
Autophagy, 2021
Innate immune response orchestrates phosphoribosyl pyrophosphate synthetases to support DNA repair.
Liu R et al.
Cell Metabolism, 2021
Translation stress and collided ribosomes are co-activators of cGAS.
Wan L et al.
Molecular Cell, 2021
Mn2+ Directly Activates cGAS and Structural Analysis Suggests Mn2+ Induces a Noncanonical Catalytic Synthesis of 2'3'-cGAMP.
Zhao Z et al.
Cell Reports, 2020
Mutant lamins cause nuclear envelope rupture and DNA damage in skeletal muscle cells.
Earle AJ et al.
Nature Materials, 2020
The cGAS/STING/TBK1/IRF3 innate immunity pathway maintains chromosomal stability through regulation of p21 levels.
Basit A et al.
Experimental & Molecular Medicine, 2020
Chromatin-bound cGAS is an inhibitor of DNA repair and hence accelerates genome destabilization and cell death.
Jiang H et al.
The Embo Journal, 2019
Bloom syndrome protein restrains innate immune sensing of micronuclei by cGAS.
Gratia M et al.
The Journal of Experimental Medicine, 2019
Structure of human cGAS reveals a conserved family of second-messenger enzymes in innate immunity.
Kranzusch PJ et al.
Cell Reports, 2013