Associated Papers
Elucidating neuroepigenetic mechanisms to inform targeted therapeutics for brain disorders.
Weekley BH et al.
Iscience, 2025
Male-Dominant Effects of Chd8 Haploinsufficiency on Synaptic Phenotypes during Development in Mouse Prefrontal Cortex.
Ellingford RA et al.
Acs Chemical Neuroscience, 2024
Neurodevelopmental functions of CHD8: new insights and questions.
Basson MA
Biochemical Society Transactions, 2024
Deletion of the autism-related gene Chd8 alters activity-dependent transcriptional responses in mouse postmitotic neurons.
Kawamura A et al.
Communications Biology, 2023
Genome-wide rare variant score associates with morphological subtypes of autism spectrum disorder.
Chan AJS et al.
Nature Communications, 2022
The phenotypic spectrum and genotype-phenotype correlations in 106 patients with variants in major autism gene CHD8.
Dingemans AJM et al.
Translational Psychiatry, 2022
Age-differential sexual dimorphism in CHD8-S62X-mutant mouse behaviors.
Lee SY et al.
Frontiers in Molecular Neuroscience, 2022
Chromatin Remodeler CHD8 in Autism and Brain Development.
Hoffmann A et al.
Journal of Clinical Medicine, 2021
Large-scale targeted sequencing identifies risk genes for neurodevelopmental disorders.
Wang T et al.
Nature Communications, 2020
De novo variants in the Helicase-C domain of CHD8 are associated with severe phenotypes including autism, language disability and overgrowth.
An Y et al.
Human Genetics, 2020
Rare genetic susceptibility variants assessment in autism spectrum disorder: detection rate and practical use.
Husson T et al.
Translational Psychiatry, 2020
Functional DNA methylation signatures for autism spectrum disorder genomic risk loci: 16p11.2 deletions and CHD8 variants.
Siu MT et al.
Clinical Epigenetics, 2019
The clinical presentation caused by truncating CHD8 variants.
Douzgou S et al.
Clinical Genetics, 2019
Autism spectrum disorder early in development associated with CHD8 mutations among two Chinese children.
Wang J et al.
Bmc Pediatrics, 2018
Mutations and Modeling of the Chromatin Remodeler CHD8 Define an Emerging Autism Etiology.
Barnard RA et al.
Frontiers in Neuroscience, 2015
Recurrent de novo mutations implicate novel genes underlying simplex autism risk.
O'Roak BJ et al.
Nature Communications, 2014
Disruptive CHD8 mutations define a subtype of autism early in development.
Bernier R et al.
Cell, 2014
Multiplex targeted sequencing identifies recurrently mutated genes in autism spectrum disorders.
O'Roak BJ et al.
Science (new York, N.y.), 2012