Associated Papers
Discriminating activating, deactivating and resistance variants in protein kinases.
Singh G et al.
Genome Medicine, 2025
41152984 (PubMed )
Supplement: 13073_2025_1564_MOESM2_ESM.xlsx › Table_S5
Nuclear ATR lysine-tyrosylation protects against heart failure by activating DNA damage response.
Zhao R et al.
Cell Reports, 2023
Small molecule inhibitors and a kinase-dead expressing mouse model demonstrate that the kinase activity of Chk1 is essential for mouse embryos and cancer cells.
Muralidharan SV et al.
Life Science Alliance, 2020
32571801 (PubMed )
Supplement: LSA-2020-00671_review_history.pdf
SPRTN protease and checkpoint kinase 1 cross-activation loop safeguards DNA replication.
Halder S et al.
Nature Communications, 2019
31316063 (PubMed )
Supplement: 41467_2019_11095_MOESM1_ESM.pdf
Mitotic arrest by tumor suppressor RASSF1A is regulated via CHK1 phosphorylation.
Jiang L et al.
Molecular Cancer Research : Mcr, 2014
Candidate tumor suppressor BTG3 maintains genomic stability by promoting Lys63-linked ubiquitination and activation of the checkpoint kinase CHK1.
Cheng YC et al.
Proceedings of the National Academy of Sciences of the United States of America, 2013
DNA damage-induced CHK1 autophosphorylation at Ser296 is regulated by an intramolecular mechanism.
Okita N et al.
Febs Letters, 2012
DNA damage induces Chk1-dependent centrosome amplification.
Bourke E et al.
Embo Reports, 2007
The relative contribution of CHK1 and CHK2 to Adriamycin-induced checkpoint.
Ho CC et al.
Experimental Cell Research, 2005
Regulatory interactions between the checkpoint kinase Chk1 and the proteins of the DNA-dependent protein kinase complex.
Goudelock DM et al.
The Journal of Biological Chemistry, 2003
Ataxia-telangiectasia-mutated (ATM) and NBS1-dependent phosphorylation of Chk1 on Ser-317 in response to ionizing radiation.
Gatei M et al.
The Journal of Biological Chemistry, 2003
Determination of substrate motifs for human Chk1 and hCds1/Chk2 by the oriented peptide library approach.
O'Neill T et al.
The Journal of Biological Chemistry, 2002
The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites.
Shieh SY et al.
Genes & Development, 2000
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