Associated Papers
Discriminating activating, deactivating and resistance variants in protein kinases.
Singh G et al.
Genome Medicine, 2025
41152984 (PubMed )
Supplement: 13073_2025_1564_MOESM2_ESM.xlsx › Table_S5
Differential response of normal and malignant urothelial cells to CHK1 and ATM inhibitors.
Wang WT et al.
Oncogene, 2015
The interaction between checkpoint kinase 1 (Chk1) and the minichromosome maintenance (MCM) complex is required for DNA damage-induced Chk1 phosphorylation.
Han X et al.
The Journal of Biological Chemistry, 2014
DNA damage-induced CHK1 autophosphorylation at Ser296 is regulated by an intramolecular mechanism.
Okita N et al.
Febs Letters, 2012
Chk1 suppresses bypass of mitosis and tetraploidization in p53-deficient cancer cells.
Wilsker D et al.
Cell Cycle (georgetown, Tex.), 2012
Targeted mutations in the ATR pathway define agent-specific requirements for cancer cell growth and survival.
Wilsker D et al.
Molecular Cancer Therapeutics, 2012
Rapid and transient recruitment of DNMT1 to DNA double-strand breaks is mediated by its interaction with multiple components of the DNA damage response machinery.
Ha K et al.
Human Molecular Genetics, 2011
Chk1 phosphorylation during mitosis: a new role for a master regulator.
Wilsker D et al.
Cell Cycle (georgetown, Tex.), 2009
A conserved proliferating cell nuclear antigen-interacting protein sequence in Chk1 is required for checkpoint function.
Scorah J et al.
The Journal of Biological Chemistry, 2008
Loss of CHK1 function impedes DNA damage-induced FANCD2 monoubiquitination but normalizes the abnormal G2 arrest in Fanconi anemia.
Guervilly JH et al.
Human Molecular Genetics, 2008
HCLK2 is essential for the mammalian S-phase checkpoint and impacts on Chk1 stability.
Collis SJ et al.
Nature Cell Biology, 2007
Regulation of Chk1 includes chromatin association and 14-3-3 binding following phosphorylation on Ser-345.
Jiang K et al.
The Journal of Biological Chemistry, 2003
Ataxia-telangiectasia-mutated (ATM) and NBS1-dependent phosphorylation of Chk1 on Ser-317 in response to ionizing radiation.
Gatei M et al.
The Journal of Biological Chemistry, 2003
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