Varaico: Literature-Extracted Genetic Variants

Gene:CHEK1
Variant:p.S345P
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CHEK1

NM_001114122.3:p.S345P

Associated Papers

The Link between Autosomal Dominant Polycystic Kidney Disease and Chromosomal Instability: Exploring the Relationship.

Chen PL et al.

International Journal of Molecular Sciences, 2024

Innate immunity mediator STING modulates nascent DNA metabolism at stalled forks in human cells.

Lazarchuk P et al.

Frontiers in Molecular Biosciences, 2022

Suppression of the FA pathway combined with CHK1 inhibitor hypersensitize lung cancer cells to gemcitabine.

Dai CH et al.

Scientific Reports, 2017

Selective Inhibition of Parallel DNA Damage Response Pathways Optimizes Radiosensitization of Glioblastoma Stem-like Cells.

Ahmed SU et al.

Cancer Research, 2015

Mitomycin C reduces abundance of replication forks but not rates of fork progression in primary and transformed human cells.

Kehrli KR et al.

Oncoscience, 2014

A small ubiquitin binding domain inhibits ubiquitin-dependent protein recruitment to DNA repair foci.

Helchowski CM et al.

Cell Cycle (georgetown, Tex.), 2013

Distinct roles of FANCO/RAD51C protein in DNA damage signaling and repair: implications for Fanconi anemia and breast cancer susceptibility.

Somyajit K et al.

The Journal of Biological Chemistry, 2012

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."