Varaico: Literature-Extracted Genetic Variants

Gene:CHEK2
Variant:p.S516A
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CHEK2

NM_007194.4:p.S516A

Associated Papers

Molecular and In Silico Analysis of the CHEK2 Gene in Individuals with High Risk of Cancer Predisposition from Türkiye.

Ozdemir O et al.

Cancers, 2024

39594831 (PubMed )
Supplement: cancers-16-03876-s001.zip › TableS2.xlsx › CHEK2_SuppTable2__1_

Stability of checkpoint kinase 2 is regulated via phosphorylation at serine 456.

Kass EM et al.

The Journal of Biological Chemistry, 2007

Characterization of CHEK2 mutations in prostate cancer.

Wu X et al.

Human Mutation, 2006

Autophosphorylation of checkpoint kinase 2 at serine 516 is required for radiation-induced apoptosis.

Wu X et al.

The Journal of Biological Chemistry, 2003

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."