Varaico: Literature-Extracted Genetic Variants

Gene:CHEK2
Variant:p.T387A
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CHEK2

NM_007194.4:p.T387A

Associated Papers

Chk2 sustains PLK1 activity in mitosis to ensure proper chromosome segregation.

Black EM et al.

Biorxiv : the Preprint Server for Biology, 2024

ENIGMA CHEK2gether Project: A Comprehensive Study Identifies Functionally Impaired CHEK2 Germline Missense Variants Associated with Increased Breast Cancer Risk.

Stolarova L et al.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research, 2023

Enhanced access to the human phosphoproteome with genetically encoded phosphothreonine.

Moen JM et al.

Nature Communications, 2022

Efficacy of immunotherapy in lung cancer with co-occurring mutations in NOTCH and homologous repair genes.

Mazzotta M et al.

Journal for Immunotherapy of Cancer, 2020

32759236 (PubMed )
Supplement: jitc-2020-000946supp001.xlsx › all_prediction_score_merged

Pancreatic cancer as a sentinel for hereditary cancer predisposition.

Young EL et al.

Bmc Cancer, 2018

KinView: a visual comparative sequence analysis tool for integrated kinome research.

McSkimming DI et al.

Molecular Biosystems, 2016

Interdependent phosphorylation within the kinase domain T-loop Regulates CHK2 activity.

Guo X et al.

The Journal of Biological Chemistry, 2010

Characterization of CHEK2 mutations in prostate cancer.

Wu X et al.

Human Mutation, 2006

The hCds1 (Chk2)-FHA domain is essential for a chain of phosphorylation events on hCds1 that is induced by ionizing radiation.

Lee CH et al.

The Journal of Biological Chemistry, 2001

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."