Associated Papers
Unconventional binding of calmodulin to CHK2 kinase inhibits catalytic activity.
Horne CR et al.
The Biochemical Journal, 2025
Comprehensive analysis of the functional impact of single nucleotide variants of human CHEK2.
McCarthy-Leo CE et al.
Plos Genetics, 2024
Functional Analysis Identifies Damaging CHEK2 Missense Variants Associated with Increased Cancer Risk.
Boonen RACM et al.
Cancer Research, 2022
The Chk2-PKM2 axis promotes metabolic control of vasculogenic mimicry formation in p53-mutated triple-negative breast cancer.
Yu P et al.
Oncogene, 2021
CHK2-FOXK axis promotes transcriptional control of autophagy programs.
Chen Y et al.
Science Advances, 2020
A pathway linking translation stress to checkpoint kinase 2 signaling in Neurospora crassa.
Diernfellner ACR et al.
Proceedings of the National Academy of Sciences of the United States of America, 2019
Deacetylation of CHK2 by SIRT1 protects cells from oxidative stress-dependent DNA damage response.
Kwon J et al.
Experimental & Molecular Medicine, 2019
Structure and activation mechanism of the CHK2 DNA damage checkpoint kinase.
Cai Z et al.
Molecular Cell, 2009
The relative contribution of CHK1 and CHK2 to Adriamycin-induced checkpoint.
Ho CC et al.
Experimental Cell Research, 2005
Differential mode of regulation of the checkpoint kinases CHK1 and CHK2 by their regulatory domains.
Ng CP et al.
The Journal of Biological Chemistry, 2004
The hCds1 (Chk2)-FHA domain is essential for a chain of phosphorylation events on hCds1 that is induced by ionizing radiation.
Lee CH et al.
The Journal of Biological Chemistry, 2001
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