Associated Papers
WDFY2 promotes MRN complex formation required for homologous recombination-mediated DNA repair.
Lu YF et al.
Cell Reports, 2025
Discriminating activating, deactivating and resistance variants in protein kinases.
Singh G et al.
Genome Medicine, 2025
Mitochondrial ROS triggers mitophagy through activating the DNA damage response signaling pathway.
Guo QQ et al.
Proceedings of the National Academy of Sciences of the United States of America, 2025
DNA damage response pathway regulates Nrf2 in response to oxidative stress.
Jiang XY et al.
Science Advances, 2025
ROS-ATM-CHK2 axis stabilizes HIF-1α and promotes tumor angiogenesis in hypoxic microenvironment.
Bai M et al.
Oncogene, 2025
A missense variant effect map for the human tumor-suppressor protein CHK2.
Gebbia M et al.
American Journal of Human Genetics, 2024
Comprehensive analysis of the functional impact of single nucleotide variants of human CHEK2.
McCarthy-Leo CE et al.
Plos Genetics, 2024
The phosphorylation-deubiquitination positive feedback loop of the CHK2-USP7 axis stabilizes p53 under oxidative stress.
Liu J et al.
Cell Reports, 2024
ATM-CHK2-TRIM32 axis regulates ATG7 ubiquitination to initiate autophagy under oxidative stress.
Liu J et al.
Cell Reports, 2023
ENIGMA CHEK2gether Project: A Comprehensive Study Identifies Functionally Impaired CHEK2 Germline Missense Variants Associated with Increased Breast Cancer Risk.
Stolarova L et al.
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research, 2023
JAK2-CHK2 signaling safeguards the integrity of the mitotic spindle assembly checkpoint and genome stability.
Chowdhury MAN et al.
Cell Death & Disease, 2022
CHK2 Promotes Metabolic Stress-Induced Autophagy through ULK1 Phosphorylation.
Guo R et al.
Antioxidants (basel, Switzerland), 2022
The Chk2-PKM2 axis promotes metabolic control of vasculogenic mimicry formation in p53-mutated triple-negative breast cancer.
Yu P et al.
Oncogene, 2021
ATM-CHK2-Beclin 1 axis promotes autophagy to maintain ROS homeostasis under oxidative stress.
Guo QQ et al.
The Embo Journal, 2020
CHK2-FOXK axis promotes transcriptional control of autophagy programs.
Chen Y et al.
Science Advances, 2020
Chk2-dependent phosphorylation of myosin phosphatase targeting subunit 1 (MYPT1) regulates centrosome maturation.
Nai S et al.
Cell Cycle (georgetown, Tex.), 2019
Functional characterization of CHEK2 variants in a Saccharomyces cerevisiae system.
Delimitsou A et al.
Human Mutation, 2019
Clarifying the biological significance of the CHK2 K373E somatic mutation discovered in The Cancer Genome Atlas database.
Higashiguchi M et al.
Febs Letters, 2016
Hepatitis C virus upregulates B-cell receptor signaling: a novel mechanism for HCV-associated B-cell lymphoproliferative disorders.
Dai B et al.
Oncogene, 2016
Distinct DNA damage determines differential phosphorylation of Chk2.
Ouchi M et al.
Cancer Biology & Therapy, 2014
γH2AX foci formation in the absence of DNA damage: mitotic H2AX phosphorylation is mediated by the DNA-PKcs/CHK2 pathway.
Tu WZ et al.
Febs Letters, 2013
Functional and molecular interactions between ERK and CHK2 in diffuse large B-cell lymphoma.
Dai B et al.
Nature Communications, 2011
Interdependent phosphorylation within the kinase domain T-loop Regulates CHK2 activity.
Guo X et al.
The Journal of Biological Chemistry, 2010
The cell cycle checkpoint kinase CHK2 mediates DNA damage-induced stabilization of TTK/hMps1.
Yeh YH et al.
Oncogene, 2009
Exploring the intramolecular phosphorylation sites in human Chk2.
Olsen BB et al.
Mutation Research, 2008
Stability of checkpoint kinase 2 is regulated via phosphorylation at serine 456.
Kass EM et al.
The Journal of Biological Chemistry, 2007
The Plk1 Polo box domain mediates a cell cycle and DNA damage regulated interaction with Chk2.
Tsvetkov LM et al.
Cell Cycle (georgetown, Tex.), 2005
Inducible degradation of checkpoint kinase 2 links to cisplatin-induced resistance in ovarian cancer cells.
Zhang P et al.
Biochemical and Biophysical Research Communications, 2005
Autophosphorylation of checkpoint kinase 2 at serine 516 is required for radiation-induced apoptosis.
Wu X et al.
The Journal of Biological Chemistry, 2003
Polo-like kinase 1 and Chk2 interact and co-localize to centrosomes and the midbody.
Tsvetkov L et al.
The Journal of Biological Chemistry, 2003
Distinct spatiotemporal dynamics of mammalian checkpoint regulators induced by DNA damage.
Lukas C et al.
Nature Cell Biology, 2003
Phosphorylation of threonine 68 promotes oligomerization and autophosphorylation of the Chk2 protein kinase via the forkhead-associated domain.
Ahn JY et al.
The Journal of Biological Chemistry, 2002
The hCds1 (Chk2)-FHA domain is essential for a chain of phosphorylation events on hCds1 that is induced by ionizing radiation.
Lee CH et al.
The Journal of Biological Chemistry, 2001