Varaico: Literature-Extracted Genetic Variants

Gene:CNOT8
Variant:p.D40A
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CNOT8

NM_001301073.2:p.D40A

Associated Papers

Mechanism of ribosome-associated mRNA degradation during tubulin autoregulation.

Höpfler M et al.

Molecular Cell, 2023

Crystal structure and functional properties of the human CCR4-CAF1 deadenylase complex.

Chen Y et al.

Nucleic Acids Research, 2021

Human Pumilio proteins directly bind the CCR4-NOT deadenylase complex to regulate the transcriptome.

Enwerem III et al.

Rna (new York, N.y.), 2021

HELZ directly interacts with CCR4-NOT and causes decay of bound mRNAs.

Hanet A et al.

Life Science Alliance, 2019

Reconstitution of recombinant human CCR4-NOT reveals molecular insights into regulated deadenylation.

Raisch T et al.

Nature Communications, 2019

The central region of CNOT1 and CNOT9 stimulates deadenylation by the Ccr4-Not nuclease module.

Pavanello L et al.

The Biochemical Journal, 2018

30309886 (PubMed )
Supplement: supplement_1.pdf

Xenopus CAF1 requires NOT1-mediated interaction with 4E-T to repress translation in vivo.

Waghray S et al.

Rna (new York, N.y.), 2015

Structural basis for the Nanos-mediated recruitment of the CCR4-NOT complex and translational repression.

Bhandari D et al.

Genes & Development, 2014

Mammalian miRNA RISC recruits CAF1 and PABP to affect PABP-dependent deadenylation.

Fabian MR et al.

Molecular Cell, 2009

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."