Varaico: Literature-Extracted Genetic Variants

Gene:COPS5
Variant:p.D151N
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COPS5

NM_006837.3:p.D151N

Associated Papers

Whole-exome sequencing for identification of specific gene mutations in an Indian cohort of triple-negative breast cancer patients.

Preeti P et al.

Discover Oncology, 2025

41324770 (PubMed )
Supplement: 12672_2025_3921_MOESM2_ESM.xlsx › Sheet1

Jun activation domain-binding protein 1 (JAB1) is required for the optimal response to interferons.

Muromoto R et al.

The Journal of Biological Chemistry, 2013

The COP9 signalosome mediates beta-catenin degradation by deneddylation and blocks adenomatous polyposis coli destruction via USP15.

Huang X et al.

Journal of Molecular Biology, 2009

The COP9/signalosome increases the efficiency of von Hippel-Lindau protein ubiquitin ligase-mediated hypoxia-inducible factor-alpha ubiquitination.

Miyauchi Y et al.

The Journal of Biological Chemistry, 2008

CSN5 binds to misfolded CFTR and promotes its degradation.

Tanguy G et al.

Biochimica Et Biophysica Acta, 2008

Targeted silencing of Jab1/Csn5 in human cells downregulates SCF activity through reduction of F-box protein levels.

Cope GA et al.

Bmc Biochemistry, 2006

Distinct aerobic and hypoxic mechanisms of HIF-alpha regulation by CSN5.

Bemis L et al.

Genes & Development, 2004

The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage.

Groisman R et al.

Cell, 2003

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."